Evidence map›Paper›PMID 41502527›Full record

ArticleOncology research2025

Huihui Shi, Lei Chen, Juan Huang, Xuejing Lin, Lei Huang, Min Tang, Kai Lu, Wenchao Wang, Maoling Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huihui ShiDepartment of Gastroenterology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China.
Lei ChenCenter for Clinical Research and Translational Medicine, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China.
Juan HuangDepartment of Surgical Room, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China.
Xuejing LinCenter for Clinical Research and Translational Medicine, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China.
Lei HuangDepartment of General Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China.
Min TangDepartment of General Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China.
Kai LuDepartment of Hepatic-Biliary-Pancreatic Surgery, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China.
Wenchao WangDepartment of General Surgery, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China.
Maoling ZhuDepartment of Gastroenterology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. This study aimed to identify key genes involved in HCC development and elucidate their molecular mechanisms, with a particular focus on mitochondrial function and apoptosis. Methods: Differential expression analyses were performed across three datasets-The Cancer Genome Atlas (TCGA)-Liver Hepatocellular Carcinoma (LIHC), GSE36076, and GSE95698-to identify overlapping differentially expressed genes (DEGs). A prognostic risk model was then constructed. Cysteine/serine-rich nuclear protein 1 ( Results: A six-gene prognostic model was established, comprising downregulated genes ( Conclusion:

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsMitochondriaNuclear ProteinsReactive Oxygen SpeciesApoptosisCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansJNK Mitogen-Activated Protein KinasesMAP Kinase Signaling Systemp38 Mitogen-Activated Protein KinasesPrognosisJNK Mitogen-Activated Protein KinasesNuclear Proteinsp38 Mitogen-Activated Protein KinasesReactive Oxygen Speciesc-Jun N-terminal kinase/p38 mitogen-activated protein kinase pathwayCysteine/serine-rich nuclear protein 1hepatocellular carcinomamitochondrial dysfunctionreactive oxygen species accumulation

Identifiers

PMID41502527
PMCPMC12774537

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.