Evidence map›Paper›PMID 41502517›Full record

ReviewOncology research2025

Salivary Biomarkers and Their Link to Oncogenic Signaling Pathways in Oral Squamous Cell Carcinoma: Diagnostic and Translational Perspectives in a Narrative Review.

Wen-Shou Tan, Hsuan Kuo, Chang-Ge Jiang, Mei-Han Lu, Yi-He Lu, Yung-Li Wang, Ching-Shuen Wang, Thi Thuy Tien Vo, I-Ta Lee

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wen-Shou TanSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Hsuan KuoDivision of Oral and Maxillofacial Surgery, Department of Dentistry, Taipei Medical University Hospital, Taipei, 11031, Taiwan.
Chang-Ge JiangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Mei-Han LuSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Yi-He LuSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Yung-Li WangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Ching-Shuen WangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan.
Thi Thuy Tien VoFaculty of Dentistry, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam.
I-Ta LeeSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 11031, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This narrative review examines recent advances in salivary biomarkers for oral squamous cell carcinoma (OSCC), a major subtype of oral cancer with persistently low five-year survival rates due to delayed diagnosis. Saliva has emerged as a noninvasive diagnostic medium capable of reflecting both local tumor activity and systemic physiological changes. Various salivary biomarkers, including microRNAs, cytokines, proteins, metabolites, and exosomes, have been linked to oncogenic signaling pathways involved in tumor progression, immune modulation, and therapeutic resistance. Advances in quantitative polymerase chain reaction, mass spectrometry, and next-generation sequencing have enabled comprehensive biomarker profiling, while point-of-care detection systems and saliva-based omics platforms are accelerating clinical translation. Remaining challenges include variability in salivary composition, lack of standardized collection protocols, and insufficient validation across large patient cohorts. This review highlights the mechanistic relevance, diagnostic potential, and translational challenges of salivary biomarkers in OSCC.

Indexed as

Biomarkers, TumorCarcinoma, Squamous CellMouth NeoplasmsSalivaHumansSignal TransductionBiomarkers, Tumornarrative reviewnon-invasive diagnosticsOral squamous cell carcinoma (OSCC)salivary biomarkerssignaling pathways

Identifiers

PMID41502517
PMCPMC12774544

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.