ArticleAnnals of translational medicine2025
Development of a novel micro-CT based scoring system for the assessment of joint structure in a rat model of inflammatory knee osteoarthritis.
Article in Annals of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Osteoarthritis (OA) is a degenerative joint disease involving cartilage loss and inflammation. Traditional histological evaluation is limited. Micro-computed tomography (micro-CT) offers non-invasive three-dimensional (3D) joint visualization but lacks detailed cartilage assessment. This study developed and evaluated a novel micro-CT-based scoring system for joint structure in a rat model of mono-iodoacetate (MIA)-induced OA. Methods: OA was induced in the right knees of 24 Wistar male rats using varying MIA concentrations (0.2, 0.5, 1, 3 mg). After 28 days, knee joints were scanned using micro-CT and segmented into 10 compartments. Degenerative changes in each compartment were scored (0-4), and a total joint score was calculated. Histological evaluation using a modified Mankin score was performed on sagittal sections of the patellar groove. Interobserver reliability and correlations between micro-CT joint scores and Mankin scores were analyzed statistically. Results: The micro-CT 3D imaging scoring system demonstrated excellent interobserver reliability [interclass correlation coefficient (ICC) >0.75 for most compartments]. Micro-CT joint scores revealed statistically significant differences in joint degeneration between the highest MIA dose group (3 mg) and the lower dose groups (0.2 and 0.5 mg). Notably, micro-CT could differentiate between the 0.2 mg and 1mg groups, which was not fully reflected in histological scores. A strong correlation was found between the total micro-CT joint score and the modified Mankin score (ρ=0.8, P<0.001). Conclusions: The novel micro-CT-based 3D imaging scoring system provides a reliable method for quantifying gross degenerative changes in rat knee joints in the MIA-induced OA model. While it does not directly assess cartilage, its correlation with histological findings suggests its utility as a complementary tool for evaluating overall joint degeneration.
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