Evidence map›Paper›PMID 41502406›Full record

ArticlePharmaceutical biology2026

Dual anti-pseudomonal and resistance-modulatory actions of

Armel Jackson Seukep, Helene Gueaba Mbuntcha, Cromwel Tepap Zemnou, Arnaud Fondjo Kouam, Victor Kuete, Mingquan Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Armel Jackson SeukepDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Buea, Buea, Cameroon.
Helene Gueaba MbuntchaDepartment of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Cromwel Tepap ZemnouEuroMed University of Fes (UEMF), Fes, Morocco.
Arnaud Fondjo KouamDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Buea, Buea, Cameroon.
Victor KueteDepartment of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Mingquan GuoLaboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextThe growing multidrug resistance (MDR) of

objectiveThis study investigated MATERIALS AND

methodsAn integrated workflow combining LC/Q-TOF-MS metabolomic profiling, molecular docking (MD), dynamics simulations (MDS), and microbiological assays was applied to the ethyl acetate fraction of the aerial parts (SAAP-EA).

resultsMetabolomic analysis identified 35 compounds, including biochanin A (BCA), resveratrol (RSV), methyl gallate (MG), 3-hydroxycinnamic acid (3-HCA), and azelaic acid (AZA), with favorable drug-likeness. Their toxicity predictions indicated low risks of acute toxicity (LD DISCUSSION AND

conclusionsThese findings establish a mechanistic basis for translating ethnopharmacology into therapeutic strategies against MDR Gram-negative pathogens. Future work should prioritize

Indexed as

Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialPlant ExtractsPseudomonas aeruginosaAnimalsBacterial ProteinsMetabolomicsMicrobial Sensitivity TestsMolecular Docking SimulationMolecular Dynamics SimulationPlant Components, AerialAnti-Bacterial AgentsBacterial ProteinsPlant Extractsantibiotic adjuvantefflux pump inhibitionmolecular dockingPseudomonas aeruginosaSida acuta

Identifiers

PMID41502406
PMCPMC12784639

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.