Evidence map›Paper›PMID 41502372›Full record

ArticleJournal of medicinal chemistry2026

Hybridization Approach Applied to Umbelliferon and Vanilloids toward New Inhibitors of Carbonic Anhydrases IX and XII with In Vitro Antiproliferative and Anti-inflammatory Activities.

Francesco Melfi, Noemi Mencarelli, Simone Carradori, Marialucia Gallorini, Andrea Angeli, Giulio Poli, Amelia Cataldi, Ilaria D'Agostino, Andrea Di Credico, Angela Di Baldassarre and 2 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesco MelfiDepartment of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy.
Noemi MencarelliDepartment of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy.
Simone CarradoriDepartment of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy.ORCID 0000-0002-8698-9440
Marialucia GalloriniDepartment of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy.
Andrea AngeliNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Firenze, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.ORCID 0000-0002-1470-7192
Giulio PoliDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0002-8061-5632
Amelia CataldiDepartment of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy.
Ilaria D'AgostinoDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Andrea Di CredicoDepartment of Medicine and Aging Sciences, ″G. d'Annunzio″, University of Chieti-Pescara, 66100 Chieti, Italy.
Angela Di BaldassarreDepartment of Medicine and Aging Sciences, ″G. d'Annunzio″, University of Chieti-Pescara, 66100 Chieti, Italy.
Tiziano TuccinardiDepartment of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.ORCID 0000-0002-6205-4069
Claudiu T SupuranNEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Firenze, via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.ORCID 0000-0003-4262-0323

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human carbonic anhydrases (hCAs) IX and XII have emerged as promising therapeutic targets and are overexpressed in hypoxic tumors. Leveraging the chemotype of umbelliferon (

Indexed as

Anti-Inflammatory AgentsAntineoplastic AgentsCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic AnhydrasesUmbelliferonesAntigens, NeoplasmCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansStructure-Activity RelationshipAntigens, NeoplasmAnti-Inflammatory AgentsAntineoplastic AgentsCA9 protein, humanCarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic Anhydrasescarbonic anhydrase XIIUmbelliferones

Identifiers

PMID41502372
PMCPMC12833850

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.