Evidence map›Paper›PMID 41502370›Full record

ArticleACS applied materials & interfaces2026

Improving Nonviral Gene Delivery by Activating Mechanosensing-Dependent Endocytic Pathways.

Flaminia Fruzzetti, Beatrice Ruzzante, Eleonora Giagnorio, Silvia Bonanno, Giuseppe Lauria Pinter, Stefania Marcuzzo, Gabriele Candiani, Nina Bono

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Flaminia FruzzettigenT_LΛB, Dept. of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Via Bassini 6, Milan 20133, Italy.
Beatrice RuzzantegenT_LΛB, Dept. of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Via Bassini 6, Milan 20133, Italy.
Eleonora GiagnorioNeurology 4- Neuroimmunology and Neuromuscular Diseases Fondazione IRCCS Istituto Neurologico "Carlo Besta", Via Celoria 11, Milan 20133, Italy.
Silvia BonannoNeurology 4- Neuroimmunology and Neuromuscular Diseases Fondazione IRCCS Istituto Neurologico "Carlo Besta", Via Celoria 11, Milan 20133, Italy.
Giuseppe Lauria PinterALS Centre, Third Neurology Unit, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Via Celoria 11, Milan 20133, Italy.
Stefania MarcuzzoNeurology 4- Neuroimmunology and Neuromuscular Diseases Fondazione IRCCS Istituto Neurologico "Carlo Besta", Via Celoria 11, Milan 20133, Italy.
Gabriele CandianigenT_LΛB, Dept. of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Via Bassini 6, Milan 20133, Italy.ORCID 0000-0003-0575-068X
Nina BonogenT_LΛB, Dept. of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Via Bassini 6, Milan 20133, Italy.ORCID 0000-0002-6891-9879

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The delivery of nucleic acids into host cells has emerged as an innovative and promising therapeutic approach for various diseases. Despite significant advances in nanoparticle delivery systems, persistent cellular barriers limit the clinical application of most existing technologies. In this study, we developed a programmable device that applies precise uniaxial cyclic stretching to cells cultured on custom polydimethylsiloxane chambers to investigate whether mechanical stimulation can enhance the transfection efficiency (TE) of gold-standard non-viral gene delivery vectors. Applying cyclic mechanical stimulation (

Indexed as

EndocytosisGene Transfer TechniquesMechanotransduction, CellularDNAHeLa CellsHumansMyoblastsPlasmidsPolyethyleneimineTransfectionDNAPolyethyleneimineendocytosisgene transfer techniquesmechanical stimulationmechanotransductionnon-viral gene deliverytransfectionYAP

Identifiers

PMID41502370
PMCPMC12884457

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.