Evidence map›Paper›PMID 41502301›Full record

ArticleGlia2026

Müller Glial Kir4.1 Channel Dysfunction in APOE4-KI Model of Alzheimer's Disease.

Surabhi D Abhyankar, Yucheng Xiao, Neha Mahajan, Qianyi Luo, Theodore R Cummins, Adrian L Oblak, Bruce T Lamb, Timothy W Corson, Ashay D Bhatwadekar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Neuroinflammation in glaucoma: a myriad of cellular pathways and players.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Surabhi D AbhyankarDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Yucheng XiaoDepartment of Biology, School of Science, Indiana University, Indianapolis, Indiana, USA.
Neha MahajanDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Qianyi LuoDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Theodore R CumminsDepartment of Biology, School of Science, Indiana University, Indianapolis, Indiana, USA.
Adrian L OblakStark Neurosciences Research Institute, Indianapolis, Indiana, USA.
Bruce T LambStark Neurosciences Research Institute, Indianapolis, Indiana, USA.
Timothy W CorsonDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Ashay D BhatwadekarDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Funding

RESEARCH TRAINING PROGRAM IN DIABETES AND OBESITYT32DK064466 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Carmella Evans-Molina, RONALD C WEK · 2003 to 2026
$5.2M
miR-92a as a biomarker of diabetic retinopathyR01EY032080 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI BHATWADEKAR, ASHAY D · 2021 to 2025
$2.6M
Retinal dysfunction in Alzheimer's disease mouse modelsR01EY027779 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI BHATWADEKAR, ASHAY D · 2017 to 2021
$2.4M
NEI NIH HHS R01 EY027779NEI NIH HHS R01 EY032080NIDDK NIH HHS T32 DK064466
6 · The paper itself

Abstract

Alzheimer's disease (AD), particularly late-onset AD (LOAD), affects millions worldwide, with the apolipoprotein ε4 (APOE4) allele being a significant genetic risk factor. Retinal abnormalities are a hallmark of LOAD, and our recent study demonstrated significant age-related retinal impairments in APOE4-knock-in (KI) mice, highlighting that retinal impairments occur before the onset of cognitive decline in these mice. Müller cells (MCs), key retinal glia, are vital for retinal health, and their dysfunction may contribute to retinal impairments seen in AD. MCs maintain potassium balance via specialized inwardly rectifying K

Indexed as

Alzheimer DiseaseApolipoprotein E4Ependymoglial CellsPotassium Channels, Inwardly RectifyingAnimalsCells, CulturedDisease Models, AnimalHumansKcnj10 ChannelMembrane Potential, MitochondrialMiceMice, TransgenicMitochondriaOxidative StressPatch-Clamp TechniquesRatsApolipoprotein E4Kcnj10 ChannelPotassium Channels, Inwardly RectifyingAPOEKir4.1late‐onset Alzheimer's diseasemitochondrial dysfunctionMüller cells

Identifiers

PMID41502301
PMCPMC12780660

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.