Evidence map›Paper›PMID 41502186›Full record

Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2026

Evaluation of a Remote Therapeutic Monitoring Device and Integrated Care Platform in Outpatient Parenteral Antimicrobial Therapy.

Emily A Siegrist, Mitchell Berenson, Justin D Dvorak, Jacob K Dozier, S Rae Wannier, Rita Wilson Dib, Brian M Scott, Nayle Ibragimova, Debbie Nail Meyer, Maria Alkozah and 6 more

Abstract readClinical Trial
In one paragraph

Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Emily A SiegristDepartment of Pharmacy, OU Health, Oklahoma City, Oklahoma, USA.ORCID 0000-0002-4282-4134
Mitchell BerensonIV Ensure, Inc, Dallas, Texas, USA.ORCID 0009-0009-9738-5165
Justin D DvorakHudson College of Public Health, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.
Jacob K DozierIV Ensure, Inc, Dallas, Texas, USA.
S Rae WannierIV Ensure, Inc, Dallas, Texas, USA.
Rita Wilson DibDivision of Infectious Diseases, Department of Medicine, College of Medicine, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.
Brian M ScottDivision of Infectious Diseases, Department of Medicine, College of Medicine, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.
Nayle IbragimovaDepartment of Pharmacy, OU Health, Oklahoma City, Oklahoma, USA.ORCID 0009-0000-7324-8670
Debbie Nail MeyerIV Ensure, Inc, Dallas, Texas, USA.ORCID 0009-0001-5027-2931
Maria AlkozahDivision of Infectious Diseases, Department of Medicine, College of Medicine, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.ORCID 0000-0002-7274-5453
Michelle SalvaggioDivision of Infectious Diseases, Department of Medicine, College of Medicine, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.
Bryan P WhiteDepartment of Pharmacy, OU Health, Oklahoma City, Oklahoma, USA.
Bushra SiddiqueDepartment of Medicine, OU Health Edmond Medical Center, Edmond, Oklahoma, USA.
Sharanjeet ThindDivision of Infectious Diseases, Department of Medicine, College of Medicine, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.ORCID 0000-0002-1660-5528
Dale W BratzlerHudson College of Public Health, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.ORCID 0000-0002-8033-7521
Joseph SassineDivision of Infectious Diseases, Department of Medicine, College of Medicine, University of Oklahoma Health Campus, Oklahoma City, Oklahoma, USA.ORCID 0000-0001-8730-8929

Funding

NIH HHS
6 · The paper itself

Abstract

backgroundUnplanned healthcare utilization events, including hospital readmissions and emergency room visits, are common in patients receiving outpatient parenteral antimicrobial therapy (OPAT). Little is known about patient adherence to therapy in this setting. This clinical trial evaluates the impact of a remote therapeutic monitoring (RTM) device with an integrated care platform on all-cause healthcare utilization in patients on OPAT.

methodsThis prospective, open-label, nonrandomized study enrolled patients discharged on OPAT to receive the IV Ensure RTM device compared to contemporaneous controls. The primary outcome was all-cause healthcare utilization, including hospital readmission or emergency room visit, assessed at day 90 after discharge. Adherence to antimicrobial therapy was evaluated in the intervention group.

resultsA total of 81 patients were enrolled in the intervention group, with 131 patients in the control group. Both groups had similar baseline and OPAT characteristics. On multivariate Cox regression analysis, the RTM intervention was associated with a 39% reduction in all-cause healthcare utilization by day 60 (adjusted hazard ratio, 0.61 [95% confidence interval, .38-.96]; P = .03]) and a 38% reduction by day 90 (0.62 [.40-.95]; P = .03). In the intervention group, the overall adherence reached a median of 94%, and 61.7% of patients maintained adherence of >90% throughout their OPAT course.

conclusionsAn RTM device with an integrated care platform significantly reduced all-cause healthcare utilization events in patients on OPAT.

Indexed as

Ambulatory CareAnti-Infective AgentsDrug MonitoringAdherence InterventionsAdultAgedDelivery of Health Care, IntegratedEmergency Room VisitsFemaleHumansMaleMiddle AgedOutpatientsPatient ReadmissionProspective StudiesRemote Patient MonitoringAnti-Infective AgentsadherenceOPATremote therapeutic monitoring

Identifiers

PMID41502186
PMCPMC13189677

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.