ReviewMedical science monitor : international medical journal of experimental and clinical research2026
Eutopic Endometrium Immune Changes Involved in Development and Progression of Endometriosis: A Review.
Review in Medical science monitor : international medical journal of experimental and clinical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Single-Cell RNA Sequencing Shows Markedly Elevated Immune Cell Proportions in the Endometrium of Women with Endometriosis-A Narrative Review.International journal of molecular sciences · 2026Review
- Elevated interleukin-33, CD1c+ dendritic cells, and interleukin-17A in peritoneal fluid of patients with endometriosis: a case-control study.Molecular biology reports · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Numerous abnormalities of the endometriosis eutopic endometrium contribute to the initiation and development of ectopic lesions. It is also believed that among the complex causes of the disease, systemic immunological disorders play a significant role. Therefore, this literature review aims to summarize the current knowledge on immunological alterations in the endometriosis eutopic endometrium and the impact of these changes on the progression of this disease. The reviewed studies mostly indicated a pro-inflammatory immunological profile within this tissue. This was evidenced by a predominance of M1 macrophages, which have a pro-inflammatory character and elevated levels of pro-inflammatory cytokines such as interleukin-1 (IL-1) or IL-6. Additionally, an increased number of cytotoxic T lymphocytes and a positive correlation between B lymphocyte levels and the presence of endometriosis have been observed. Some changes in T cells and natural killer (NK) cells receptors, which possibly determine endometriosis development, have been described. Several studies have also revealed that patients with endometriosis exhibit reduced presence of dendritic cells in the eutopic endometrium of affected individuals, which may impair uterine cavity clearance during menstruation and contribute to ectopic lesion formation. In summary, current data indicate a pivotal role of the endometrial immune environment in disease progression, but further research is needed to drive development of immunological treatment in endometriosis management.
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Registered trials
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