ReviewChinese medicine2026
The scientific basis of synergy in traditional Chinese medicine: physicochemical, pharmacokinetic, and pharmacodynamic perspectives.
Review in Chinese medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comprehensive evaluation of the efficacy and safety of different vitamin D combination regimens based on indirect comparisons for children with rickets: a network meta-analysis.Frontiers in nutrition · 2026Pooled it
- Exosome-like nanoparticles derived fromInternational journal of pharmaceutics: X · 2026Article
- Integrated UPLC-MS/MS profiling and network pharmacology-based analysis of the anti-hyperglycemic potential of Baihu Jia Renshen Decoction combined with Sanghuangporus vaninii extract in mice.Journal of molecular histology · 2026Article
- Aconitine from Aconiti Lateralis Radix Praeparata (Fuzi) Suppresses Intrahepatic Cholangiocarcinoma via TOP2A: A Study Combining Machine Learning with Functional Validation.Chinese journal of integrative medicine · 2026Article
- Mechanisms of pruritus and advances in traditional Chinese medicine therapy (Review).Molecular medicine reports · 2026Review
- Distributed Pharmacodynamic Architecture in Multi-Component Herbal Formulations: A Flux-Based Framework for Redox-Heterogeneous Diseases.Pharmaceutics · 2026Review
- Dietary Astragalus Crude Extract Boosts Piglet Growth and Mitigates Weaning Stress by Enhancing Antioxidant Activity, Improving Immunity, and Modulating Intestinal Microbiota.Veterinary sciences · 2026Article
- Oxidative stress driven airway mesenchymal reprogramming in asthma: mechanistic insights and evidence from botanical drug formulations.Frontiers in pharmacology · 2026Review
- Comprehensive phytochemical profiling of dealcoholized zhuyeqing liquor extract and its protective effect on hyperuricemia by regulating urate transporters and LPS/NLRP3 inflammasome pathway.Frontiers in nutrition · 2026Article
- Molecular mechanisms of traditional Chinese medicine in skin aging: a narrative review.Frontiers in pharmacology · 2026Review
- Exploring the medicinal value of Boletus from the dual perspectives of modern pharmacology and traditional Chinese medicine theory.Frontiers in pharmacology · 2026Review
- An integrated annotation strategy for the phytochemical characterization of Xie-Bai-San decoction based on UPLC-Q Exactive Orbitrap HRMS, multi-database screening, and feature-based molecular networking.Frontiers in chemistry · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Traditional Chinese medicine, with millennia of history, demonstrates significant therapeutic efficacy against diverse diseases. A key characteristic of traditional Chinese medicine lies in the use of compound formulas-multi-herb concoctions that enhance efficacy and mitigate toxicity. The synergy within these formulas arises fundamentally from interactions among multiple active components. Recently, growing experimental studies have aimed to elucidate the scientific principles underlying synergy in traditional Chinese medicine. By reviewing literature over the past 30 years, this review summarizes that traditional Chinese medicine synergy manifests primarily through three key mechanisms: physicochemical interactions, pharmacokinetic processes, and pharmacodynamic effects. Furthermore, it provides an overview of methodological advances for studying these mechanisms, including HPLC fingerprinting, network pharmacology, and metabolomics, among others. Finally, it highlights current research limitations as well as challenges in traditional Chinese medicine modernization. This review systematically synthesizes current knowledge on traditional Chinese medicine synergy to establish a foundation for compatibility research and promote evidence-based clinical application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.