Evidence map›Paper›PMID 41501886›Full record

Observational studyCritical care (London, England)2026

Early lung ultrasound score changes predict the failure of non-invasive respiratory supports in acute hypoxemic patients: a multicenter prospective observational study.

Silvia Mongodi, Erminio Santangelo, Domenico Luca Grieco, Valeria Musella, Nello De Vita, Rosanna Vaschetto, Bélaïd Bouhemad, Francesco Mojoli

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Critical care (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Silvia MongodiAnesthesia and Intensive Care, Fondazione IRCCS Policlinico San Matteo, Viale Golgi 19, Pavia, Italy. mongodi.silvia@gmail.com.
Erminio SantangeloInterdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
Domenico Luca GriecoDepartment of Emergency, Intensive Care Medicine and Anesthesia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Valeria MusellaSSD Biostatistica e Clinical Trial Center, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Nello De VitaDepartment of Translational Medicine, Eastern Piedmont University, Novara, Italy.
Rosanna VaschettoDepartment of Translational Medicine, Eastern Piedmont University, Novara, Italy.
Bélaïd BouhemadDijon and Université Bourgogne Franche-Comté, LNC UMR866, Dijon, F-21000, 77908, 21709, Bourgogne-Franche-Comté, France.
Francesco MojoliDepartment of clinical-surgical, diagnostic and pediatric sciences, Unit of anaesthesia and intensive care, University of Pavia, Pavia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo determine whether lung ultrasound (LUS) may early predict the failure of non-invasive respiratory support (high-flow nasal cannula-HFNC, continuous positive airway pressure-CPAP, non-invasive ventilation-NIV) in hypoxemic patients.

methodsIn this prospective multicenter international observational study, we enrolled patients undergoing non-invasive treatments for hypoxemia (PaO

resultsWe studied 100 patients (age 70 [57-76] years; female sex 39%; supports: 13 HFNC, 68 CPAP, 19 NIV); the overall rate of treatment failure was 22%. At the baseline, clinical and ultrasound parameters were similar in failing and non-failing patients; after 2 h, failing patients had lower PaO

conclusionsChanges in LUS aeration scores induced by 2 h of non-invasive respiratory support help early predict the risk of treatment failure. LUS score improved only in responders and was an independent predictor of failure.

Indexed as

HypoxiaLungNoninvasive VentilationAgedContinuous Positive Airway PressureFemaleHumansMaleMiddle AgedPredictive Value of TestsProspective StudiesTreatment FailureUltrasonographyAcute respiratory failureHFNC, CPAP, NIV, ROX indexLung ultrasound aeration scoreNon-invasive respiratory support

Identifiers

PMID41501886
PMCPMC12870349

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.