ArticleBMC endocrine disorders2026
Correlation of skeletal muscle mass and visceral fat area with hyperuricemia in male adolescents.
Article in BMC endocrine disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe prevalence of hyperuricemia (HUA) has been increasing among adolescents, yet the relationship between body composition and HUA remains underexplored. This study aimed to investigate the association between different body composition parameters and HUA in adolescents.
methodsThis cross-sectional study included 230 male adolescents aged 10–20 years from Taizhou Hospital of Zhejiang Province, with 148 in the HUA group and 82 in the control (non-HUA) group, with a mean age of 16.0 ± 2.3 years. Data were collected on demographics, body composition (skeletal muscle mass [SMM] and visceral fat area [VFA]), and laboratory parameters, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), glucose (GLU), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), total cholesterol (TC), and serum uric acid (UA).
resultsIn this study, 148 male adolescents (64.35%) were diagnosed with HUA. Pearson correlation analysis revealed that serum UA levels were positively correlated with SMM (r = 0.371, P < 0.001), VFA (r = 0.500, P < 0.001), and body mass index (BMI) (r = 0.504, P < 0.001). Multivariate logistic regression analysis showed that, after adjusting for major determinants such as age, weight status (based on BMI categories), AST, HDL-C, and GLU, SMM (OR = 1.125, 95% CI: 1.032–1.226, P = 0.007) and VFA (OR = 1.024, 95% CI: 1.007–1.041, P = 0.005) remained independent risk factors for HUA. When participants were grouped based on SMM (cutoff: 30.10 kg) and VFA (cutoff: 63.30 cm²), those with SMM ≥ 30.10 kg and VFA ≥ 63.30 cm² exhibited significantly higher HUA prevalence and serum UA levels compared to those with SMM < 30.10 kg and VFA < 63.30 cm² (P < 0.001). Additionally, serum UA levels increased progressively with higher weight status.
conclusionOur study confirms that SMM and VFA are positively correlated with serum UA levels and the prevalence of HUA in adolescent males, with this association influenced by body weight status. Therefore, in clinical practice, in addition to focusing on BMI, greater emphasis should be placed on evaluating SMM and VFA to develop more comprehensive strategies for the prevention and intervention of HUA risk in adolescents. CLINICAL TRIAL NUMBER: Not applicable.
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