ArticleBMC nephrology2026
Health-related quality of life in nondialysis CKD patients: a comprehensive description of five-year trajectories among the CKD-REIN cohort.
Article in BMC nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew studies have analyzed the quality-of-life trajectories of CKD patients not receiving kidney replacement therapy, and the results are inconsistent. This study aimed to identify subgroups of long-term trajectories of the physical (PCS) and mental components summary (MCS) of the KDQOL-36 in patients with CKD stages 3-5 and to describe their associations with patient characteristics.
methodsWe used a joint latent class-mixed model to identify the PCS and MCS trajectories of 2716 patients with CKD stages 3-5 enrolled in the CKD-Renal Epidemiology and Information Network (CKD-REIN) cohort study. Quality-of-life was assessed annually using the Kidney Disease Quality-of-life-36. All the participants had scores for at least one-time point.
resultsDuring a median follow-up of 5.56 (4.77-6.16) years, 664 participants started KRT, and 465 died before KRT. We identified three profiles of PCS: a "High and declining PCS trajectory" which included 5.89% of patients, characterized by a higher initial score and a decline of more than 10 points over three years; a "High and stable PCS trajectory" in 50.96%, characterized by a higher initial score that remained stable; and a "Low and stable PCS trajectory" in 43.15%, characterized by a lower initial score that remained stable. For MCS, we identified a single, stable mean trajectory over time. A decline in eGFR was faster in participants with a "High and declining PCS trajectory" (-4.30 mL/min per years). Patients in the high and stable trajectory had a more favorable clinical and biological profile at baseline. The evolution of the specific dimensions of CKD within each PCS trajectory followed a pattern similar to that of the PCS itself.
conclusionsThe study highlights substantial heterogeneity in PCS evolution in patients with CKD, which contrasts with the stability of that for MCS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.