ArticleBMC cardiovascular disorders2026
Association of triglyceride-glucose related indices with cardiovascular diseases in individuals with low handgrip strength: a prospective cohort study of UK biobank.
Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLow handgrip strength (HGS) predicts cardiovascular disease (CVD) risk, potentially via insulin resistance (IR). The triglyceride-glucose (TyG) index and its combinations with adiposity measures (TyG-BMI, TyG-WC, TyG-WHtR) enhance CVD prediction, but the prognostic value in low HGS populations is unknown.
methodsThis UK Biobank prospective cohort study analyzed 18,341 participants with low HGS (mean age 59.2 years, 61.2% female). Multivariable Cox models assessed associations between TyG-related indices and incident CVD, coronary heart disease (CHD) and stroke. Subgroup and mediation analyses identified effect modifiers and pathways; sensitivity analyses validated result robustness.
resultsOver 13.4 median years, 2,666 CVD cases occurred. Per 1-SD increase, TyG, TyG-BMI, TyG-WC and TyG-WHtR were significantly associated with higher CVD incidence (adjusted HRs: 1.08, 1.13, 1.15, 1.15 respectively; all p < 0.001). TyG-related indices showed significant interaction effects for CVD/CHD across subgroups including age, disease status and medication use. Mediation analyses indicated dyslipidemia, inflammation and IR mediated the associations.
conclusionsElevated TyG-related indices independently predict increased CVD and CHD incidence in individuals with low HGS, offering value for early risk identification and the development of preventive strategies.
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