ArticleBMC immunology2026
Lactate dehydrogenase to albumin ratio as a convenient parameter for predicting the severity of Behçet disease: a cross-sectional study.
Article in BMC immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06276829 (A Convenient Parameter for Predicting Behçet's Disease Severity), which is not on this map. Not yet cited in PubMed.
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A Convenient Parameter for Predicting Behçet's Disease Severity: Lactate Dehydrogenase/Albumin Ratio
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2 authors.
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Abstract
backgroundWe investigated whether the ratio of lactate dehydrogenase (LDH) to albumin could be used as a diagnostic marker for Behçet's disease compared to the healthy population and as a marker to assess the severity and activity of the disease.
methodsThe research was conducted as a cross-sectional study. Patients aged 18-69 years presenting to the Behçet's disease Outpatient Clinic over a three-year period and healthy individuals with a similar age and gender distribution formed the two study groups. LDH and albumin levels, and the LDH/albumin ratio were compared between the groups.
resultsThe study was conducted in 349 people, 160 patients with Behçet's disease and 189 healthy controls. The LDH/albumin ratio was significantly higher in the Behçet's group than in the control group. This ratio was significantly different according to the severity of the disease, the presence of genital ulcers, papulopustular lesions and joint involvement (p < 0.05). Duration of symptoms was positively correlated with LDH/albumin ratio values (r = 0.259, p = 0.001). ROC analysis of the LDH/albumin ratio in the severe versus not severe groups based on Behçet's disease severity showed an area under the curve (AUC) of 0.704 (95% CI: 0.586-0.821) and a cut-off value of 57.46, with a sensitivity of 57.7% and specificity of 72.4%.
conclusionThe LDH/albumin ratio is a promising parameter in patients diagnosed with Behçet's disease compared to healthy controls, with a cut-off value of 57.46 for distinguishing severe from non-severe disease.
trial registrationThis study was registered under ID number NCT06276829 (Study Record Dates:18.02.2024).
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