ArticleBMC cardiovascular disorders2026
Left ventricular geometric patterns and systolic myocardial performance in Nigerian children with homozygous sickle cell anaemia.
Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Blood Pressure Abnormalities Amongst Children with Sickle Cell Anaemia in Steady State and in Crises Attending a Tertiary Hospital in South East Nigeria.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
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7 authors.
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Abstract
backgroundCardiac complications contribute significantly to morbidity in children with sickle cell anaemia (SCA). Little is known about the geometry and contractile function of the left ventricle (LV) of affected children in sub-Saharan Africa, which has the greatest burden of this disease.
objectiveTo compare the LV systolic function of children with SCA in the steady state with that of matched haemoglobin AA controls.
methodsClinical, laboratory and LV M-mode echocardiographic parameters of 120 steady-state SCA patients aged 3–14 years were compared with those of matched Hb AA controls. Univariate and multivariate analyses were performed using SPSS software, version 22 (IBM, Armonk, NY, USA).
resultsThe median ejection fraction of 62.00 (IQR = 55.0–67.0) for the subjects was significantly less than that of 68.00 (IQR = 65.8–73.0) for the controls (p < 0.001) and correlated negatively with age (ρ=-0.25, p = 0.006), BSA (ρ=-0.24, p = 0.008), systolic BP (ρ=-0.23, p = 0.022), and diastolic BP (ρ=-0.31, p = 0.002). Left ventricular systolic dysfunction (LVSD) was present in 27% of the SCA patients but only in 1% of the controls (χ² = 26.5, p < 0.001). The odds of having LVSD decreased by 0.9 for every 1% increase in HbF level (CI = 0.82–0.99, p = 0.03). Abnormal LV geometry, detected in 52% of the subjects, was associated with the presence of LVSD (Fisher’s exact test, p < 0.001). The odds of having abnormal LV geometry decreased by 0.5 for every 1 g increase in Hb level (CI = 0.27–0.87, p = 0.02).
conclusionsLVSD is more common in SCA patients than in controls and is less likely to occur in patients with higher HbF levels. Approximately one in every two children with SCA have abnormal LV geometry, which is less likely to occur at higher Hb levels.
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