Evidence map›Paper›PMID 41501466›Full record

ArticleNature2026

Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit.

Vladislav Pokatayev, Alok Jaiswal, Angela R Shih, Åsa Segerstolpe, Bihua Li, Elizabeth A Creasey, Yanhua Zhao, Crystal Lin, Shane Murphy, Chih-Hung Chou and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Vladislav Pokatayev *Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alok Jaiswal *Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Angela R ShihDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8945-5997
Åsa SegerstolpeKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Bihua LiDepartment of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Elizabeth A CreaseyCenter for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yanhua ZhaoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Crystal LinKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4005-3556
Shane MurphyKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Chih-Hung ChouBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5714-1718
Daniel B GrahamCenter for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. dgraham@broadinstitute.org.ORCID http://orcid.org/0000-0002-8403-8115
Ramnik J XavierCenter for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.ORCID http://orcid.org/0000-0002-5630-5167

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
Universite de Montreal IBD Genetics Research CenterU01DK062432 · NIDDK · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI John D. Rioux · 2002 to 2026
$9.6M
Spatial and temporal resolution to dissect cellular circuits controlling intestinal physiology, immunity, and inflammatory pathologiesRC2DK135492 · NIDDK · BROAD INSTITUTE, INC. · PI Caroline Uhler, Ramnik J Xavier · 2023 to 2026
$7.9M
NIDDK NIH HHS P30 DK043351NIDDK NIH HHS RC2 DK135492NIDDK NIH HHS U01 DK062432
6 · The paper itself

Abstract

The stromal cell compartment plays a central part in the maintenance of tissue homeostasis by coordinating with the immune system throughout inception, amplification and resolution of inflammation

Identifiers

PMID41501466
PMCPMC12820784

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.