ArticleNature2026
An expanded registry of candidate cis-regulatory elements.
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In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
0numbers the graph read from it
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40citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
40 citing papers in PubMed.
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- Identification and evaluation of 41 risk loci for juvenile idiopathic arthritis informs precision medicine: mechanistic implications of DNA topology and an HLA-A*02:01-ERAP2 interaction.medRxiv : the preprint server for health sciences · 2026Article
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- Epistemological parameters in the recent era of nuclear organization and function.Molecular biology of the cell · 2026Review
- The stress-induced transcription factor ATF4 has multiple conserved retrocopies that can alter gene expression.HGG advances · 2026Article
- Inherited Susceptibility to Urinary Tract Infections from Kidney Papilla to Bladder.medRxiv : the preprint server for health sciences · 2026Article
- Identification of DNA-Binding Factor Enrichment in Chromatin Accessibility Data to Define a Persister Cell Signature.Bio-protocol · 2026Article
- Chromatin topology and distal elements underlie divergent cell-type-specific regulation of 9p21 locus cell cycle genes.Cell genomics · 2026Article
- Article
- Pig Matrix: a matched multiomics 3D regulatory genomics database for evolutionary and comparative analyses in pigs.Molecular biology and evolution · 2026Article
- Massively parallel characterization and predictive modelling of neuronal regulatory variation.bioRxiv : the preprint server for biology · 2026Article
- KOLF2.1J iTF-Microglia: A standardized platform to study microglial transcriptional regulatory networks in CNS disease.iScience · 2026Article
- Reference Regulatory Element-Guided Gene Expression Analysis for Mechanistic Inference of Gene Regulatory Networks.bioRxiv : the preprint server for biology · 2026Article
- The Encyclopedia of DNA Elements.bioRxiv : the preprint server for biology · 2026Article
- Integrating multi-ancestry common and rare variant mapping accelerates therapeutic target discovery.medRxiv : the preprint server for health sciences · 2026Article
- Limited Selection on Neanderthal DNA in 30,780 Recently Admixed Genomes with African-like Ancestry.Molecular biology and evolution · 2026Article
- Identifying severe COVID-19 risk variants modulating enhancer reporter activity in lung cells.PLoS genetics · 2026Article
- Live-cell imaging of enhancer-promoter dynamics reveals transient contact-driven gene activation.bioRxiv : the preprint server for biology · 2026Article
- SMARCD1 and Its Functional Relevance in SWI/SNF and Cancer.International journal of molecular sciences · 2026Review
- The nascent transcriptome delineates the regulatory landscape in human health and disease.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
- Update of
Authors and funding
49 authors.
Jill E MooreDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA. Jill.Moore@umassmed.edu.ORCID http://orcid.org/0000-0002-3023-0806
Henry E PrattDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Kaili FanDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-8723-7902
Nishigandha PhalkeDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Jonathan FisherDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Shaimae I ElhajjajyDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Gregory AndrewsDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Mingshi GaoDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-7524-892X
Nicole SheddDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Yu FuDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Matthew C LacadieDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Jair MezaDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Mansi KhandpekarDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Mohit GannaDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Eva ChoudhuryDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Ross SwoffordDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0003-3676-8479
Huong PhanDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0009-0006-2339-3806
Christian C RamirezDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Maxwell CampbellDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0009-0001-6352-0463
Mary LikhiteDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Nina P FarrellBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Annika K WeimerDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9944-8769
Anusri PampariDepartment of Computer Science, Stanford University, Stanford, CA, USA.
Vivekanandan RamalingamDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3631-8913
Fairlie ReeseDevelopmental and Cell Biology, University of California Irvine, Irvine, CA, USA.
Beatrice BorsariProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-4357-3557
Xuezhu YuProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
Eve WattenbergProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
Marina Ruiz-RomeroCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID http://orcid.org/0000-0002-8382-1052
Milad Razavi-MohseniDepartment of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
Jinrui XuDepartment of Biology and Center for Applied Data Science and Analytics, Howard University, Washington, DC, USA.
Timur GaleevProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.
Andres ColubriDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA.
Michael A BeerDepartment of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-9955-3809
Roderic GuigóCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID http://orcid.org/0000-0002-5738-4477
Mark B GersteinProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-9746-3719
Jesse M EngreitzDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5754-1719
Mats LjungmanDepartments of Radiation Oncology and Environmental Health Sciences, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1553-6695
Timothy E ReddyDuke Center for Statistical Genetics and Genomics, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-7629-061X
Michael P SnyderDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0784-7987
Charles B EpsteinBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8358-8345
Elizabeth GaskellBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Bradley E BernsteinBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5726-6278
Diane E DickelEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Axel ViselEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-4130-7784
Len A PennacchioEnvironmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-8748-3732
Ali MortazaviDevelopmental and Cell Biology, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-4259-6362
Anshul KundajeDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3084-2287
Zhiping WengDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA, USA. zhiping.weng@umassmed.edu.ORCID http://orcid.org/0000-0002-3032-7966
Funding
PRODUCTION CENTER FOR MAPPING REGULATORY REGIONS OF THE HUMAN GENOMEUM1HG009442 · NHGRI · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2017 to 2021
$20.1MHigher Precision Human and Mouse TranscriptomesUM1HG009443 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MORTAZAVI, SEYED ALI, WOLD, BARBARA J · 2017 to 2021
$15.5MA Catalog of Cell Types and Genomic Elements in Tissues, Organoids and DiseaseUM1HG009390 · NHGRI · BROAD INSTITUTE, INC. · PI BERNSTEIN, BRADLEY EVAN · 2017 to 2021
$11.0MEDAC: ENCODE Data Analysis CenterU24HG009446 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GERSTEIN, MARK BENDER, WENG, ZHIPING · 2017 to 2022
$10.4MIn Vivo Characterization of Major ENCODE-Predicted Classes of Noncoding ElementsUM1HG009421 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PENNACCHIO, LEN ALEXANDER, VISEL, AXEL · 2017 to 2021
$6.8MRegulatory Mechanisms of CD4+ T Cell DifferentiationUM1HG009428 · NHGRI · DUKE UNIVERSITY · PI CIOFANI, MARIA, CRAWFORD, GREGORY E · 2017 to 2021
$4.6MSystematic Identification of Core Regulatory Circuitry from ENCODE DataU01HG009380 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI BEER, MICHAEL A · 2017 to 2021
$2.6MMapping of Novel Candidate Functional Elements with Bru-Seq TechnologyUM1HG009382 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LJUNGMAN, MATS · 2017 to 2021
$2.3MDecoding cis-regulatory element activity through deep learning frameworksR35GM160300 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Jill Elizabeth Moore · 2025 to 2026
$921kEvaluating the utility of cis-regulatory element graphs for modeling gene regulationR03OD036496 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MOORE, JILL ELIZABETH · 2023 to 2023
$335kNHGRI NIH HHS U01 HG009380NHGRI NIH HHS U24 HG009446NHGRI NIH HHS UM1 HG009382NHGRI NIH HHS UM1 HG009390NHGRI NIH HHS UM1 HG009421NHGRI NIH HHS UM1 HG009428NHGRI NIH HHS UM1 HG009442NHGRI NIH HHS UM1 HG009443NIGMS NIH HHS R35 GM160300NIH HHS R03 OD036496
Abstract
Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.