Evidence map›Paper›PMID 41501453›Full record

ArticleNature2026

ipRGC properties prevent light from shifting the SCN clock during daytime.

Ruchi Komal, Corinne Beier, Amurta Nath, William N Grimes, Hui Wang, Michael Berry, Claire Gao, Steven Yang, Martina Thurman, Grayson P Ostermeyer and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ruchi Komal *Section on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA. ruchi.komal@nih.gov.ORCID 0000-0003-4464-680X
Corinne Beier *Section on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-0698-7219
Amurta Nath *Synaptic Physiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-7009-6883
William N GrimesSynaptic Physiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA.
Hui WangSection on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0009-0002-6021-2833
Michael BerryDepartment of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0001-5292-641X
Claire GaoSection on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-8832-5103
Steven YangSection on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0009-0004-4659-7591
Martina ThurmanSection on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0009-0004-6667-649X
Grayson P OstermeyerDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
John BallRetinal Neurophysiology Unit, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-8849-6308
Wei LiRetinal Neurophysiology Unit, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-2897-649X
R Lane BrownDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Mario PenzoSection on the Neural Circuits of Emotion and Motivation, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-5368-1802
Benjamin SivyerDepartment of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0002-4537-5768
Jeffrey S DiamondSynaptic Physiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA.
Haiqing ZhaoDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-4275-9843
Samer HattarSection on Light and Circadian Rhythms, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA. samer.hattar@nih.gov.ORCID 0000-0002-3124-9525

Funding

Section on Light and Circadian RhythmsZIAMH002964 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI HATTAR, SAMER · 2017 to 2025
$24.1M
Dissecting the stress circuits of the paraventricular nucleus of the thalamusZIAMH002950 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PENZO, MARIO · 2016 to 2025
$17.5M
Rodent Behavioral Core: The Analysis of BehaviorZICMH002952 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI CHUDASAMA, YOGITA · 2016 to 2025
$7.5M
Regulation of the intrinsic melanopsin-based light response in ipRGCsR01EY027202 · NEI · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI RONALD Lane BROWN, Joseph Leffler · 2017 to 2026
$5.3M
Molecular mechanisms of retinal ON-bipolar cell signalingR01EY029985 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI DUVOISIN, ROBERT M, MORGANS, CATHERINE W · 2019 to 2023
$2.6M
Intramural NIH HHS ZIA MH002950Intramural NIH HHS ZIA MH002964Intramural NIH HHS ZIC MH002952NEI NIH HHS R01 EY027202NEI NIH HHS R01 EY029985
6 · The paper itself

Abstract

The suprachiasmatic nucleus (SCN), the central circadian pacemaker, receives photic input exclusively from intrinsically photosensitive retinal ganglion cells (ipRGCs)

Indexed as

Circadian ClocksCircadian RhythmRetinal Ganglion CellsSuprachiasmatic NucleusAnimalsFemaleLightMaleMiceMice, Inbred C57BLTime Factors

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.