Evidence map›Paper›PMID 41501426›Full record

SynthesisAesthetic plastic surgery2026

Stromal Vascular Fraction-Assisted Fat Grafting: A Systematic Review and Meta-analysis of Clinical Outcomes.

Zainalabden E Jefri, Rasha H Alashjaee, Abdullah K Almarri, Abdulaziz M Alghamdi, Ibrahim R Halawani, Ghadah S Algoraini, Amal A Alshehri, Ghadeer M Alqahtani, Raghad S AlOubili, Remaz A Alhassan and 1 more

Abstract readSystematic ReviewMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zainalabden E JefriFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Rasha H AlashjaeePlastic and Reconstructive Surgery Department, Security Forces Hospital, Riyadh, Saudi Arabia.
Abdullah K AlmarriPostgraduate studies, Reconstructive Microsurgery European School (RMES), Affiliated with the Universitat Autònoma de Barcelona, Barcelona, Spain.
Abdulaziz M AlghamdiPlastic and Reconstructive Surgery Department, King Saud Medical City, Riyadh, Saudi Arabia.
Ibrahim R HalawaniCollege of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Ghadah S AlgorainiCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Amal A AlshehriFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Ghadeer M AlqahtaniMinistry of Health Asir Central Hospital, Abha, Saudi Arabia.
Raghad S AlOubiliCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Remaz A AlhassanCollege of Medicine, Jazan University, Jazan, Saudi Arabia. RemazAbdulaziz1@gmail.com.ORCID 0009-0006-4095-3940
Zahir T FadelDivision of Plastic Surgery, Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutologous fat grafting is a cornerstone in plastic and reconstructive surgery, yet its efficacy remains limited by variable resorption rates. Stromal vascular fraction (SVF) has emerged as a promising adjunct to enhance graft survival. This systematic review and meta-analysis aimed to evaluate the efficacy and safety of SVF-enriched fat grafting compared with conventional fat grafting techniques.

methodsA comprehensive literature search was conducted across Web of Science, PubMed, Embase, Ovid Cochrane, and Google Scholar up to September 2025, following PRISMA guidelines. Eligible studies included randomized controlled trials and observational studies comparing SVF-enriched and conventional fat grafting. Risk of bias was assessed using the Cochrane Risk of Bias 2 (RoB-2) tool for randomized trials, and both the Newcastle-Ottawa Scale (NOS) and the Risk of Bias in Non-Randomized Studies of Interventions (ROBINS-I) tool for observational studies. A random-effects model was used to calculate pooled mean differences and risk ratios, with heterogeneity assessed using the I

resultsEighteen studies involving eight hundred ninety-three patients were included. SVF-enriched fat grafting demonstrated significantly higher fat retention rates compared with conventional grafting (mean difference: 17.20%; 95% CI: 11.26-23.15; p < 0.001), though heterogeneity remained high (I

conclusionSVF-assisted fat grafting appears to enhance volumetric persistence and overall graft survival without increasing complications, supporting its potential as a safe and effective adjunct in both reconstructive and esthetic surgery. While findings are promising, further high-quality randomized controlled trials with standardized SVF isolation protocols and long-term follow-up are essential to confirm these outcomes and establish best-practice guidelines for clinical implementation. LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

Adipose TissueStromal Vascular FractionFemaleGraft SurvivalHumansTransplantation, AutologousTreatment OutcomeAdipose-derived stem cells (“ADSC”)Fat transferMeta-analysisStromal vascular fractionVolume maintenance

Identifiers

PMID41501426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.