Evidence map›Paper›PMID 41501365›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2026

Evaluation of brain conductivity changes after three-month antihypertensive medication in patients with essential hypertension.

Il Suk Sohn, Minseo Kim, Mun Bae Lee, Eunche Hyeon, So-Young Yang, Hyungseok Seo, Oh In Kwon, Soonchan Park, Chang-Woo Ryu, Geon-Ho Jahng

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In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Il Suk SohnDepartment of Cardiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Minseo KimDepartment of Biomedical Engineering, Undergraduate School, College of Electronics and Information, Kyung Hee University, Gyeonggi-do, Republic of Korea.
Mun Bae LeeDepartment of Mathematics, College of Basic Science, Konkuk University, Seoul, Republic of Korea.
Eunche HyeonDepartment of Biomedical Engineering, Undergraduate School, College of Electronics and Information, Kyung Hee University, Gyeonggi-do, Republic of Korea.
So-Young YangDepartment of Cardiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Hyungseok SeoDepartment of Anesthesiology and Pain Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Oh In KwonDepartment of Biomedical Engineering, Undergraduate School, College of Electronics and Information, Kyung Hee University, Gyeonggi-do, Republic of Korea.
Soonchan ParkDepartment of Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Chang-Woo RyuDepartment of Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Republic of Korea.
Geon-Ho JahngDepartment of Radiology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Republic of Korea. ghjahng@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study investigates brain conductivity changes following a three-month antihypertensive treatment in 22 patients with essential hypertension. Utilizing a prospective, cross-sectional design, the research employed MREPT for brain conductivity mapping. Image analyses involved voxel-based and ROI-based techniques with statistical tests examining correlations between conductivity changes and age or blood pressure changes. Key findings included a significant increase in brain conductivity post-treatment, particularly in the anterior cingulate and right insula. Older patients exhibited smaller conductivity increases, notably in the corpus callosum. No significant correlation was found between changes in diastolic or systolic blood pressure and conductivity. Proposed mechanisms for these changes include improved cerebrospinal fluid dynamics, enhanced ion mobility, and normalized ion concentrations, suggesting brain conductivity as a potential biomarker for treatment efficacy. The study implies that brain conductivity could serve as a novel imaging biomarker for monitoring antihypertensive treatment efficacy in the brain.

Indexed as

Antihypertensive AgentsBrainEssential HypertensionAgedBlood PressureCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesAntihypertensive AgentsAge effectBrain conductivityHypertensive patientImplemental hypertensionThree months of medication

Identifiers

PMID41501365

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.