Evidence map›Paper›PMID 41501348›Full record

ArticleScientific reports2026

Chelesta-8,24-dien-3-ol in Ficus exasperata leaves enhances the prevention of sodium nitrite-induced hypoxia by binding to HIF-1 and NF-κB.

Dorcas Ibukun Akinloye, Ceaser Antiya Moses, Esther Ugo Alum, Theophilus Aghogho Jarikre, Toluwalase Ayobami Adeosun, Abdulazeez Timileyin Kolawole, Iyanu Solomon Awonaiya, Esther Oluwabusayomi Odeniyi, Oluseyi Adeboye Akinloye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dorcas Ibukun AkinloyeDepartment of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria. akinloyedi@funaab.edu.ng.ORCID http://orcid.org/0000-0001-5289-9087
Ceaser Antiya MosesDepartment of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.
Esther Ugo AlumDepartment of Research and Publications, Kampala International University, Main Campus, P. O. Box 20000, Kampala, Uganda.
Theophilus Aghogho JarikreDepartment of Veterinary Pathology, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Nigeria.
Toluwalase Ayobami AdeosunDepartment of Chemistry, College of Physical Sciences, Federal University of Agriculture, Abeokuta, Nigeria.
Abdulazeez Timileyin KolawoleDepartment of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.
Iyanu Solomon AwonaiyaDepartment of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.
Esther Oluwabusayomi OdeniyiDepartment of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.
Oluseyi Adeboye AkinloyeDepartment of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In-silico and in-vivo methods were used to study Ficus exasperata leaves' n-hexane ethyl acetate fraction (NHEAF) phytochemicals that may protect against NaNO

Indexed as

FicusHypoxiaHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha SubunitNF-kappa BPlant ExtractsPlant LeavesSodium NitriteAnimalsAntioxidantsFemaleHumansRatsRats, WistarAntioxidantsHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha SubunitNF-kappa BPlant ExtractsSodium NitriteCholesta-8,24-dien-3-olHuman inducible factor-1 (HIF-1)Hypoxic stressNuclear factor kappa-B (NF-κB)Sodium nitrite

Identifiers

PMID41501348
PMCPMC12873133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.