ArticleScientific reports2026
Abnormal epigenetic aging of epigenetic outliers in normal colon mucosa from colorectal cancer patients.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Global Hypomethylation in Cell-Free DNA Enables Noninvasive Colorectal Cancer Screening: Results from a Retrospective Validation Study.Computational and structural biotechnology journal · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
A subset of colorectal cancer (CRC) patients displays abnormal DNA methylation patterns (“Outlier Methylation Phenotype” (OMP)) in normal adjacent tissue (NAT). We analyzed the impact of OMP status on epigenetic age and tumor progression using published aging and mitotic clocks and colonic epigenetic clock (EpiAge) developed on controls, with equal representation from Black and Caucasian populations. Three aging clocks (including EpiAge) showed “significantly lower” epigenetic age in CRC. Mitotic clocks suggested significantly fewer stem cell divisions in CRC versus controls. A binomial model using inactive X chromosome CpGs suggested that NAT of CRC patients had fewer stem cells compared with controls. On comparing NAT and tumor methylome, the OMP group showed the fewest epigenetic differences. In conclusion, our study demonstrates that NAT of OMP-CRC patients undergoes epigenetic age deceleration and have fewer epigenetic differences with tumor tissues, suggesting that NAT of OMPs had progressed toward a tumor identity.
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