ArticleArchives of virology2026
A natural isolate of Dione juno nucleopolyhedrovirus with a 76-bp deletion in the viral cathepsin-coding sequence fails to induce host liquefaction.
Article in Archives of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alphabaculoviruses rel, in combination with natural putrefaction, on the auxiliary genes v-cath and chiA for host liquefaction, a process that is critical for virus release and horizontal transmission. Here, we describe DijuNPV-DF/23, a natural isolate infecting the passion fruit caterpillar Dione juno that fails to induce liquefaction. PCR amplification of the v-cath/chiA locus revealed a shorter amplicon compared to a previously reported virus, DijuNPV-Araguarina, suggesting gene disruption. Genome sequencing confirmed a 122,265-bp genome with 152 ORFs and a major structural alteration: v-cath was fragmented into two truncated ORFs due to a 76-nt deletion, while chiA remained intact. This provides a direct molecular explanation for the observed non-liquefying phenotype.
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