Evidence map›Paper›PMID 41501175›Full record

ArticleBritish journal of cancer2026

Transient centrosome loss in cultured prostate epithelial cells induces chromosomal instability to produce an oncogenic genotype that correlates with poor clinical outcomes.

Jiawen Yang, John M Ryniawec, Diogo de Oliveira Pessoa, Matthew R Coope, Daniel W Buster, Emily Loertscher, Mengdie Wang, Chen Chen, Anne E Cress, Megha Padi and 1 more

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Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Jiawen YangDepartment of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA.
John M RyniawecDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
Diogo de Oliveira PessoaBiostatistics and Bioinformatics Shared Resource, University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
Matthew R CoopeDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
Daniel W BusterDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
Emily LoertscherDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
Mengdie WangDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
Chen ChenDepartment of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA.
Anne E CressDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.
Megha PadiDepartment of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA. mpadi@arizona.edu.
Gregory C RogersDepartment of Cellular and Molecular Medicine, University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA. gcrogers@arizona.edu.

Funding

U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA009213U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA242226U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA251729
6 · The paper itself

Abstract

backgroundChromosomal instability (CIN) is a hallmark of prostate cancer that strongly correlates with metastatic burden and appears prominently in both primary cancer and metastatic disease. Low Gleason score primary prostate tumors display pervasive centrosome loss, a known mechanistic driver of CIN, that disrupts normal spindle assembly and increases mitotic errors. Previously, we found that transient depletion of centrosomes in immortalized, non-tumorigenic prostate epithelial cells (PrEC) induced a burst of CIN, generating cell lines capable of forming xenograft tumors.

methodsWe used a multi-omics approach that integrates genomic and transcriptomic data to identify the oncogenic alteration signatures caused by transient centrosome loss.

resultsWe identified a consensus set of focal copy-number variations (CNVs) induced by centrosome loss in cultured cells that are also detectable within a subset of samples from a prostate cancer patient cohort. Using this CNV signature, we were able to derive a unique transcriptomic signature (CIN9) from prostate cancer patient samples that showed strong predictive value for adverse clinical outcomes.

conclusionsOur experimental system uses centrosome loss to promote a punctuated burst of genomic crisis that is characteristic of genome evolution during prostate cancer progression. Consequently, this prostate cancer model produced recurrent structural variations that are detectable in patient samples and associate with worse outcomes.

Indexed as

CentrosomeChromosomal InstabilityEpithelial CellsProstateProstatic NeoplasmsAnimalsCell Line, TumorDNA Copy Number VariationsGenotypeHumansMaleMice

Identifiers

PMID41501175
PMCPMC12960840

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.