Evidence map›Paper›PMID 41501162›Full record

ArticleScientific reports2026

Mechanism study of circCCDC134 regulating the biological behaviors of PDGF-BB-induced oral mucosal fibroblast.

Yutong Zhou, Ni Jian, Qi Wang, Canhua Jiang, Haodong Guo, Jie Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yutong ZhouDepartment of Immunology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, 410078, China.
Ni JianDepartment of Immunology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, 410078, China.
Qi WangDepartment of Immunology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, 410078, China.
Canhua JiangDepartment of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, 410078, China.
Haodong GuoDepartment of Immunology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, 410078, China.
Jie WangDepartment of Immunology, Xiangya School of Basic Medical Sciences, Central South University, Changsha, 410078, China. wj0988@csu.edu.cn.

Funding

Natural Science Foundation of Hunan Province, China 2022JJ30695
6 · The paper itself

Abstract

The transition of fibroblasts into myofibroblasts is a key factor in oral submucous fibrosis (OSF) pathogenesis. Our previous studies demonstrated that platelet-derived growth factor-BB (PDGF-BB) promotes the proliferation, migration, and transition of human oral mucosal fibroblasts (HOMF) by downregulating microRNA-503 (miR-503). However, the mechanism underlying PDGF-BB-mediated miR-503 downregulation remained unclear. We identified eight exon-derived circRNA with m

Indexed as

BecaplerminFibroblastsMicroRNAsMyofibroblastsOral Submucous FibrosisRNA, CircularAdolescentAdultCell MovementCell ProliferationGene Expression RegulationHumansMAP Kinase Signaling SystemMouth MucosaPrimary Cell Cultureraf KinasesBecaplerminMicroRNAsMIRN503 microRNA, humanraf KinasesRNA, CircularCircCCDC134MiR-503Oral submucous fibrosisPlatelet-derived growth factor-BBRAF/MEK/ERK signaling pathway

Identifiers

PMID41501162
PMCPMC12864962

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.