Evidence map›Paper›PMID 41501146›Full record

ArticleScientific reports2026

Synthesis and biological evaluation, network pharmacology, and molecular docking of 2-benzylidene-1-indanone derivatives as antitumor agents.

Xuemei Liao, Ruirong Zhuang, Tangting Zhuang, Meijiao Xie, Beidou Zhou

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xuemei LiaoSchool of Pharmacy and Medical Technology, Putian University, Putian, 351100, China.
Ruirong ZhuangPutian Lanhai Nuclear Medical Research Center, Putian, 351100, China.
Tangting ZhuangSchool of Pharmacy and Medical Technology, Putian University, Putian, 351100, China.
Meijiao XieSchool of Pharmacy and Medical Technology, Putian University, Putian, 351100, China.
Beidou ZhouSchool of Pharmacy and Medical Technology, Putian University, Putian, 351100, China. 491986737@qq.com.

Funding

Project Approved by Fujian Shanhe Pharmaceutical Co., LTD 2022AHX211(L)Putian City Science and Technology Plan Project 2021S2001-9
6 · The paper itself

Abstract

In this study, 45 2-benzylidene-1-indolone compounds were synthesized and their antitumor activities were evaluated. Experimental results demonstrated that these compounds exhibited varying degrees of inhibition against cancer cell proliferation. Notably, compound 20 showed significant activity against HGC-27 gastric cancer cells, with a half-maximal inhibitory concentration (IC

Indexed as

Antineoplastic AgentsBenzylidene CompoundsIndansMolecular Docking SimulationCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansSignal TransductionStructure-Activity RelationshipAntineoplastic AgentsBenzylidene CompoundsIndans2-benzylidene-1-indanoneAntitumor activityMolecular dockingNetwork pharmacologySynthesis

Identifiers

PMID41501146
PMCPMC12867990

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.