Evidence map›Paper›PMID 41501017›Full record

ArticleNature communications2026

Airway immune profiles and therapeutic implications of IGF1 in eosinophilic granulomatosis with polyangiitis.

Cong Dong, Bingtai Lu, Changhao Zhong, Changxing Ou, Xiaojing Yang, Lingwei Wang, Xiaoyu Zuo, Lingna Xue, Chenyang Lu, Shang Wang and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Effects ofBiology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Cong Dong *State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Bingtai Lu *State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Changhao Zhong *State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Changxing Ou *State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Xiaojing Yang *State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Lingwei Wang *Department of Pulmonary and Critical Care Medicine, Shenzhen Institute of Respiratory Diseases, Shenzhen People's Hospital, Shenzhen, Guangdong, China.ORCID http://orcid.org/0000-0003-3567-0613
Xiaoyu Zuo *State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Lingna XueState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Chenyang LuState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Shang WangState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Junjie WenState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Jianjuan MaState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Zhenan DengState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Yiyi LiuState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Liuheyi MaState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Ming LiuState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Andrew M LewThe Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Manali MukherjeeFirestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0002-7924-7211
Parameswaran NairFirestone Institute for Respiratory Health, St Joseph's Healthcare & Department of Medicine, McMaster University, Hamilton, ON, Canada.ORCID http://orcid.org/0000-0002-1041-9492
Nanshan ZhongState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0003-2515-5589
Rongchang ChenState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China. chenrc@vip.163.com.ORCID http://orcid.org/0000-0001-7642-3921
Zhanghua ChenState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China. zhanghua.chen@gwcmc.org.ORCID http://orcid.org/0000-0002-2505-0675
Yuxia ZhangState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China. yuxia.zhang@gwcmc.org.ORCID http://orcid.org/0000-0003-2715-0925
Qingling ZhangState Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China. zqling@gzhmu.edu.cn.ORCID http://orcid.org/0000-0002-2433-2849

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma (SEA) share a Type 2 (T2) inflammatory signature but exhibit distinct pathophysiology. We hypothesized that EGPA involves additional inflammatory mechanisms, beyond T2 immunity, that drive its systemic manifestations and treatment resistance. Using single-cell RNA sequencing, we identify interferon (IFN-I)-driven inflammation in EGPA, in contrast to TNF predominant pathway activation in SEA. IL1B

Indexed as

AsthmaEosinophiliaGranulomatosis with PolyangiitisInsulin-Like Growth Factor IAnimalsDisease Models, AnimalEosinophilsFemaleHumansInflammationMacrophagesMaleMiceNeutrophilsInsulin-Like Growth Factor I

Identifiers

PMID41501017
PMCPMC12873431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.