Evidence map›Paper›PMID 41500847›Full record

ArticleThorax2026

Significance of diffusing capacity of the lungs for carbon monoxide on chronic thromboembolic pulmonary hypertension.

Shun Minatsuki, Masaru Hatano, Kouta Funakoshi, Yu Taniguchi, Shiro Adachi, Takumi Inami, Kazuya Hosokawa, Jun Yamashita, Hitoshi Ogino, Ichizo Tsujino and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Shun MinatsukiDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan sminatsuki-tky@umin.ac.jp.ORCID http://orcid.org/0000-0002-1997-9269
Masaru HatanoDepartment of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
Kouta FunakoshiCenter for Clinical and Translational Research, Kyushu University Hospital, Fukuoka, Japan.
Yu TaniguchiDepartment of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Shiro AdachiDepartment of Cardiology, Nagoya University, Nagoya, Japan.
Takumi InamiDepartment of Cardiovascular Medicine, Kyorin University School of Medicine, Tokyo, Japan.
Kazuya HosokawaDepartment of Cardiovascular Medicine, Kyushu University, Fukuoka, Japan.
Jun YamashitaDepartment of Cardiology, Tokyo Medical University, Tokyo, Japan.
Hitoshi OginoDepartment of Cardiovascular Surgery, Tokyo Medical University, Tokyo, Japan.
Ichizo TsujinoDivision of Respiratory and Cardiovascular Innovative Research, Hokkaido University, Sapporo, Japan.
Nobuhiro YaoitaDepartment of Cardiovascular Medicine, Tohoku University Hospital, Sendai, Japan.
Nobutaka IkedaDepartment of Cardiovascular Medicine, Toho University Medical Center Ohashi Hospital, Tokyo, Japan.
Nobuhiro TanabeDepartment of Pulmonary Hypertension Center, Chibaken Saiseikai Narashino Hospital, Narashino, Japan.
Hiroto ShimokawaharaDepartment of Cardiology, National Hospital Organization Okayama Medical Center, Okayama, Japan.
Kayoko KubotaDepartment of Cardiovascular Medicine and Hypertension, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Ayako ShigetaDepartment of Respirology, Chiba University Graduate School of Medicine, Chiba, Japan.
Koichiro TatsumiDepartment of Respirology, Chiba University Graduate School of Medicine, Chiba, Japan.
Koshin HorimotoDepartment of Cardiovascular Medicine, Matsuyama Red Cross Hospital, Matsuyama, Japan.
Yoshito OgiharaDepartment of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan.
Yoshihiro DohiDepartment of Cardiovascular Medicine, Kure Kyosai Hospital, Kure, Japan.
Takahiro HiraideDepartment of Cardiology, Keio University School of Medicine, Tokyo, Japan.
Takashi KawakamiDivision of Cardiology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.
Hidekazu IkemiyagiDepartment of Cardiovascular Medicine, Nephrology, and Neurology, University of the Ryukyus, Okinawa, Japan.
Yuichi TamuraPulmonary Hypertension Center, International University of Health and Welfare Mita Hospital, Tokyo, Japan.
Yoshihiro FukumotoDivision of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan.
Kohtaro AbeDepartment of Cardiovascular Medicine, Kyushu University, Fukuoka, Japan.
CTEPH AC Registry Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reduced diffusing capacity of the lungs for carbon monoxide (DLco) reflects microvasculopathy in chronic thromboembolic pulmonary hypertension, yet its clinical value is uncertain. In a Japanese nationwide registry (2018-2023) we studied 1270 patients: 486 formed an event cohort and 299 a treatment cohort who underwent pulmonary endarterectomy or balloon pulmonary angioplasty. Lower baseline DLco was indicative of smaller postprocedural improvements in mean pulmonary artery pressure, pulmonary vascular resistance and cardiac index (all p≤0.023) and a higher risk of clinical events (HR 0.971, p=0.005). Outcomes deteriorated below 59.6%, indicating DLco may help stratify prognosis and treatment benefit.

Indexed as

Carbon MonoxideHypertension, PulmonaryPulmonary Diffusing CapacityPulmonary EmbolismAgedAngioplasty, BalloonChronic DiseaseEndarterectomyFemaleHumansJapanMaleMiddle AgedPrognosisRegistriesVascular ResistanceCarbon MonoxidePulmonary Embolism

Identifiers

PMID41500847
PMCPMC13479677

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.