Evidence map›Paper›PMID 41500518›Full record

ArticleAmerican journal of physiology. Renal physiology2026

Processing of ENaC in mouse kidney: effects of aldosterone and a Liddle syndrome mutation.

Gustavo Frindt, Lei Yang, Theresa Rohan, Lawrence G Palmer

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gustavo FrindtDepartment of Biochemistry and Biophysics, Weill Cornell Medicine, New York, New York, United States.ORCID 0000-0001-8280-5352
Lei YangDepartment of Biochemistry and Biophysics, Weill Cornell Medicine, New York, New York, United States.
Theresa RohanDepartment of Biochemistry and Biophysics, Weill Cornell Medicine, New York, New York, United States.ORCID 0009-0004-6643-9769
Lawrence G PalmerDepartment of Biochemistry and Biophysics, Weill Cornell Medicine, New York, New York, United States.ORCID 0000-0001-7702-4703

Funding

Regulation of ENaC Trafficking and Activity in the KidneyR01DK111380 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI PALMER, LAWRENCE G · 2017 to 2025
$3.1M
HHS | National Institutes of Health (NIH) R01DK111380NIDDK NIH HHS R01 DK111380
6 · The paper itself

Abstract

We investigated the interplay between the mineralocorticoid aldosterone and a mutation mimicking Liddle syndrome in the control of the processing of the epithelia Na

Indexed as

AldosteroneEpithelial Sodium ChannelsKidneyLiddle SyndromeMutationAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLSodiumSodium, DietaryAldosteroneEpithelial Sodium ChannelsSodiumSodium, DietarycleavageCNTDCT2ENaCsalt repletion

Identifiers

PMID41500518
PMCPMC12947310

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.