Evidence map›Paper›PMID 41500423›Full record

ArticleJournal of advanced research2026

Genotype-driven variations in lncRNA expression underlie predisposition to high-grade serous ovarian cancer.

Mingming Lu, Yanan Chu, Ziwei Zhu, Hong Zhou, Danfei Zhu, Siyi Chen, Congfan Bu, Qiheng Qian, Chen Gao, Meiye Jiang and 13 more

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Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

23 authors.

Mingming LuDepartment of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang 310052, China; Liangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou, Zhejiang 311121, China; National Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China; China National Center for Bioinformation, Beijing 100101, China; Beijing Institute of Genomices, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Yanan ChuChina National Center for Bioinformation, Beijing 100101, China; Beijing Institute of Genomices, Chinese Academy of Sciences, Beijing 100101, China.
Ziwei ZhuDepartment of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang 310052, China; Liangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou, Zhejiang 311121, China.
Hong ZhouDepartment of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang 310052, China; Liangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou, Zhejiang 311121, China.
Danfei ZhuDepartment of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang 310052, China; Liangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou, Zhejiang 311121, China.
Siyi ChenDepartment of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang 310052, China; Liangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou, Zhejiang 311121, China.
Congfan BuNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China; China National Center for Bioinformation, Beijing 100101, China; Beijing Institute of Genomices, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Qiheng QianNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China; China National Center for Bioinformation, Beijing 100101, China; Beijing Institute of Genomices, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Chen GaoHaiDe College, Ocean University of China, Qingdao 266003, China.
Meiye JiangNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China; China National Center for Bioinformation, Beijing 100101, China; Beijing Institute of Genomices, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Hao ZhangNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China; China National Center for Bioinformation, Beijing 100101, China; Beijing Institute of Genomices, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Jinyue WangNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China; China National Center for Bioinformation, Beijing 100101, China; Beijing Institute of Genomices, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Jingyao ZengNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China; China National Center for Bioinformation, Beijing 100101, China; Beijing Institute of Genomices, Chinese Academy of Sciences, Beijing 100101, China.
Zhewen ZhangNational Genomics Data Center, China National Center for Bioinformation, Beijing 100101, China; China National Center for Bioinformation, Beijing 100101, China; Beijing Institute of Genomices, Chinese Academy of Sciences, Beijing 100101, China.
Qiong ZhaoDepartment of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang 310052, China; Liangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou, Zhejiang 311121, China.
Shuai LiuLiangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou, Zhejiang 311121, China.
Xudong FuLiangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou, Zhejiang 311121, China.
Na KongLiangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou, Zhejiang 311121, China.
Francis Km ChanLiangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou, Zhejiang 311121, China.
Yongcheng WangLiangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou, Zhejiang 311121, China; Department of Laboratory Medicine of The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, China.
Guangyi JiangZhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, China; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China. Electronic address: jianggy@zjcc.org.cn.
Yu KangChina National Center for Bioinformation, Beijing 100101, China; Beijing Institute of Genomices, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: kangy@big.ac.cn.
Xin ShengDepartment of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang 310052, China; Liangzhu Laboratory, Zhejiang University, 1369 West Wenyi Road, Hangzhou, Zhejiang 311121, China. Electronic address: shengxin@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNew effective early diagnosis strategies and therapeutic targets are desperately needed for high-grade serous ovarian cancer (HGSOC). Previous functional interpretation of HGSOC genome-wide association studies (GWAS) have largely overlooked the role of long non-coding RNAs (lncRNAs).

objectivesOur study aims to identify novel causal genes, particularly lncRNAs, that contribute to HGSOC susceptibility and to explore whether their may provide preliminary insights relevant to early detection or therapeutic development.

methodsWe mapped genotype effects on the expression of both protein-coding genes (PCGs) and lncRNAs in 348 HGSOC tumor samples. By performing Bayesian colocalization analysis, we prioritized causal genes in HGSOC tumors and whole blood, respectively. Next, we generated a single-nucleus full-length transcriptome map of HGSOC tumor using snRandom-seq. Furthermore, we conducted in vitro assays to validate the functional role of lncRNA CRHR1-IT1 in HGSOC.

resultsOur findings reveal that genetic variants significantly drive expression changes in both PCGs and lncRNAs. Notably, lncRNAs contribute a greater proportion of HGSOC heritability than PCGs. Using Bayesian colocalization analysis, we prioritized 22 high-fidelity causal genes in HGSOC tumors and whole blood, including ARL17A and CRHR1-IT1. Through snRandom-seq, we characterized the single-cell expression patterns of candidate susceptibility PCGs and lncRNAs in HGSOC tumors. Furthermore, we showed that elevated CRHR1-IT1 expression promotes apoptosis and inhibits the growth of HGSOC cells in vitro.

conclusionOur study highlights the significant regulatory role of genetic variants on both protein-coding genes and lncRNAs in HGSOC. While these findings enhance our understanding of HGSOC susceptibility and may inform future efforts toward biomarker discovery or immune-related therapeutic exploration.

Indexed as

Cystadenocarcinoma, SerousGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseOvarian NeoplasmsRNA, Long NoncodingCell Line, TumorFemaleGenome-Wide Association StudyGenotypeHumansNeoplasm GradingRNA, Long NoncodingColocalizationCRHR1-IT1eQTLlncRNAOvarian cancerpost-GWAS

Identifiers

PMID41500423
PMCPMC13669595

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