Evidence map›Paper›PMID 41500309›Full record

Observational studyEnvironmental research2026

Household air pollution exposure is associated with perturbations in metabolic pathways in human milk: An observational untargeted metabolomics analysis from Guatemala.

Jada Hoyle-Gardner, Ziyin Tang, Donghai Liang, Anaite Diaz-Artiga, Ajay Pillarisetti, Luke Naeher, Kasthuri Sivalogan, Erick Mollinedo, Jiantong Wang, Thomas F Clasen and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Environmental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jada Hoyle-GardnerHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA. Electronic address: jada.hoyle-gardner@emory.edu.
Ziyin TangGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA. Electronic address: ziyin.tang@emory.edu.
Donghai LiangGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA. Electronic address: donghai.liang@emory.edu.
Anaite Diaz-ArtigaCentro de Estudios en Salud, Universidad del Valle de Guatemala, Guatemala City, Guatemala. Electronic address: adiaz@ces.uvg.edu.gt.
Ajay PillarisettiDivision of Environmental Health Sciences, University of California at Berkeley, Berkeley, CA, USA. Electronic address: ajaypillarisetti@berkeley.edu.
Luke NaeherDepartment of Environmental Health Sciences, College of Public Health, University of Georgia, Athens, GA, 30602, USA. Electronic address: lnaeher@uga.edu.
Kasthuri SivaloganNutrition and Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, 30322, USA. Electronic address: kasthuri.sivalogan@emory.edu.
Erick MollinedoDepartment of Environmental Health Sciences, College of Public Health, University of Georgia, Athens, GA, 30602, USA. Electronic address: erick.mollinedo@uga.edu.
Jiantong WangDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA. Electronic address: jiantong.wang@emory.edu.
Thomas F ClasenGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA. Electronic address: thomas.f.clasen@emory.edu.
Lisa M ThompsonFamily Health Care Nursing, University of California San Francisco, CA, 94143, USA. Electronic address: lisa.thompson@ucsf.edu.
Sheela S SinharoyHubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, 30322, USA. Electronic address: sssinh2@emory.edu.

Funding

Household Air Pollution and Health: A Multi-Country LPG Intervention TrialUM1HL134590 · NHLBI · EMORY UNIVERSITY · PI CHECKLEY, WILLIAM, CLASEN, THOMAS F · 2016 to 2021
$31.1M
Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI Dana Boyd Barr · 2013 to 2026
$22.6M
Graduate and Postdoctoral Training in ToxicologyT32ES012870 · NIEHS · EMORY UNIVERSITY · PI Carmen Joseph Marsit · 2004 to 2026
$9.1M
The Omics and Mixtures Integration on Traffic exposure and Preterm Birth (OMIT-PTB) StudyR01ES035738 · NIEHS · EMORY UNIVERSITY · PI Donghai Liang · 2024 to 2026
$2.0M
NHLBI NIH HHS UM1 HL134590NIEHS NIH HHS P30 ES019776NIEHS NIH HHS R01 ES035738NIEHS NIH HHS T32 ES012870
6 · The paper itself

Abstract

backgroundExposure to air pollutants including particulate matter (PM

methodsHuman milk samples from 75 women participating in the Household Air Pollution Intervention Network trial in Jalapa, Guatemala were obtained during household visits at six months postpartum. Samples were analyzed for metabolomic profiling using liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS). 24-hour personal exposure to PM

resultsWe extracted 571, 492, and 690 metabolic features in the C18 and 93, 1381, and 909 features in the hydrophilic interaction liquid chromatography (HILIC) columns, for PM

conclusionsHousehold air pollution exposure from PM

Indexed as

Air PollutantsAir Pollution, IndoorEnvironmental ExposureMetabolic Networks and PathwaysMilk, HumanAdultCarbon MonoxideFemaleGuatemalaHumansMetabolomeMetabolomicsParticulate MatterPregnancyYoung AdultAir PollutantsCarbon MonoxideParticulate MatterBlack carbonCarbon monoxideLiquified petroleum gasMetabolome-wide association studyParticulate matter (PM(2.5))

Identifiers

PMID41500309
PMCPMC13719185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.