Evidence map›Paper›PMID 41499553›Full record

ArticlePloS one2026

Effect of exercise preconditioning on myocardial content of Sphingosine1-phosphate and its mechanism in rats after exhaustive exercise.

Xinnuan Wei, Weiyuan Yang, Junxiang Zhou, Luoyuan Cao, Wenxing Jiang

Erratum issuedAbstract read
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In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Xinnuan WeiNingde Clinical Medical College of Fujian Medical University, Ningde, Fujian, People's Republic of China.
Weiyuan YangNingde Clinical Medical College of Fujian Medical University, Ningde, Fujian, People's Republic of China.ORCID https://orcid.org/0009-0005-8511-2718
Junxiang ZhouNingde Clinical Medical College of Fujian Medical University, Ningde, Fujian, People's Republic of China.
Luoyuan CaoDepartment of Rehabilitation Medicine, Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian, People's Republic of China.
Wenxing JiangNingde Clinical Medical College of Fujian Medical University, Ningde, Fujian, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to investigate the effects of exercise preconditioning on rat myocardial Sphingosine1-phosphate(S1P) content and its potential mechanisms of heart protection.

methodsA rat model of exercise preconditioning followed by exhaustive exercise was established. Rats were randomized to four groups: control (C), exercise preconditioning (EP), EP plus the S1PR1-selective antagonist W146 (EP + W146), and EP plus the MEK1/2 inhibitor PD98059 (EP + PD98059). Following a final exhaustive swim, comparisons across groups revealed that EP attenuated myocardial injury and apoptosis, an effect which was abolished by both W146 and PD98059.

results1. Exercise preconditioning (EP) significantly attenuated exhaustive exercise-induced myocardial injury and apoptosis (P < 0.001); 2. EP significantly elevated myocardial S1P levels (P = 0.002), and S1PR1-selective antagonist (W146) abolished this cardioprotective effect (P = 0.016 for apoptosis); 3. Most importantly, MAPK pathway inhibition (PD98059) abrogated the protective effect of EP, as evidenced by significantly increased apoptosis (P = 0.002), despite unaltered S1P levels.

conclusionIn summary, beyond confirming S1P elevation with exercise preconditioning, our findings propose the S1P→MAPK signaling axis as a novel mechanistic pathway warranting future validation.

Indexed as

LysophospholipidsMyocardiumPhysical Conditioning, AnimalSphingosineAnimalsApoptosisFlavonoidsMaleRatsRats, Sprague-DawleyReceptors, LysosphingolipidSphingosine-1-Phosphate Receptors2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-oneFlavonoidsLysophospholipidsReceptors, LysosphingolipidS1PR1 protein, ratSphingosinesphingosine 1-phosphateSphingosine-1-Phosphate Receptors

Identifiers

PMID41499553
PMCPMC12779141

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.