Evidence map›Paper›PMID 41499513›Full record

ArticleScience advances2026

Quantitative modulation of a spatial enhancer through the biophysical properties of a transcription factor binding site.

Conrad Fallon, Liucong Ling, Brendon H Cooper, Stefano Ceolin, Tsu-Pei Chiu, Raktim Mitra, Bettina Mühling, Vani Srinivasan, Ayse Damla Durmaz, Daniel Veselinovic and 8 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Conrad FallonUniversity of Bonn, Bonn Institute for Organismic Biology, Bonn, Germany.ORCID 0009-0002-0331-7284
Liucong LingUniversity of Bonn, Bonn Institute for Organismic Biology, Bonn, Germany.ORCID 0000-0002-1754-6902
Brendon H CooperDepartment of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0009-0000-8395-5651
Stefano CeolinLudwig-Maximilians Universität München, Fakultät für Biologie, Biozentrum, Planegg-Martinsried, Germany.
Tsu-Pei ChiuDepartment of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-2472-6557
Raktim MitraDepartment of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0003-1182-3742
Bettina MühlingLudwig-Maximilians Universität München, Fakultät für Biologie, Biozentrum, Planegg-Martinsried, Germany.ORCID 0000-0003-4901-0560
Vani SrinivasanLudwig-Maximilians Universität München, Fakultät für Biologie, Biozentrum, Planegg-Martinsried, Germany.ORCID 0009-0003-9581-5092
Ayse Damla DurmazLudwig-Maximilians Universität München, Fakultät für Biologie, Biozentrum, Planegg-Martinsried, Germany.
Daniel VeselinovicLudwig-Maximilians Universität München, Fakultät für Biologie, Biozentrum, Planegg-Martinsried, Germany.ORCID 0009-0003-2754-5836
Mahek KothariLudwig-Maximilians Universität München, Fakultät für Biologie, Biozentrum, Planegg-Martinsried, Germany.ORCID 0009-0006-8971-4203
Athanasios Panagiotis FylaktakisDepartment of Biology, University of Crete, Voutes University Campus, Heraklion, Crete 70013, Greece.
William J GlassfordDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0003-4007-6731
Judith F Kribelbauer-SwietekDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-8072-7773
Dimitrios K PapadopoulosDepartment of Biology, University of Crete, Voutes University Campus, Heraklion, Crete 70013, Greece.ORCID 0000-0003-0914-3051
Richard S MannDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-4749-2765
Remo RohsDepartment of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0003-1752-1884
Nicolas GompelUniversity of Bonn, Bonn Institute for Organismic Biology, Bonn, Germany.ORCID 0000-0003-3358-7963

Funding

Interpreting and Deploying Genomic Information During Animal DevelopmentR35GM118336 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RICHARD S MANN · 2016 to 2026
$6.9M
Quantitative Modeling of Transcription Factor-DNA BindingR35GM130376 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Remo Rohs · 2019 to 2026
$3.3M
NIGMS NIH HHS R35 GM118336NIGMS NIH HHS R35 GM130376
6 · The paper itself

Abstract

Fine-tuning of gene expression by transcription factors (TFs) is essential for normal development, but how TF binding is converted into precise expression levels is poorly understood. We used a

Indexed as

Drosophila ProteinsEnhancer Elements, GeneticTranscription FactorsAnimalsBinding SitesBiophysical PhenomenaDrosophilaDrosophila melanogasterGene Expression Regulation, DevelopmentalProtein BindingWings, AnimalDrosophila ProteinsTranscription Factors

Identifiers

PMID41499513
PMCPMC12778045

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.