ArticleScience advances2026
The Yeh pilus adhesin is equipped with an α-helical flap motif, which contributes to pectin adherence.
Kevin O Tamadonfar, Roger D Klein, Edward D B Lopatto, Maxwell I Zimmerman, Philippe N Azimzadeh, Denise A Sanick, Justin R Porter, Jesus Bazan Villicana, Jerome S Pinkner, Bo Huey Chiang and 6 more
Abstract read
In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Kevin O TamadonfarDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6481-9993 Roger D KleinDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, USA.
Edward D B LopattoDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6625-6143 Maxwell I ZimmermanDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.
Philippe N AzimzadehDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-8172-5051 Denise A SanickDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-6903-0273 Justin R PorterDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-0340-951X Jesus Bazan VillicanaDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-8724-3213 Jerome S PinknerDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-7389-7440 Bo Huey ChiangDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, CA, USA.ORCID 0009-0004-0411-8310 Nathaniel C GualbertoDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0009-0009-2697-5862 Karen W DodsonDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, USA.
Michael L PatnodeDepartment of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, CA, USA.ORCID 0000-0003-1981-5261 George M H BirchenoughDepartment of Medical Biochemistry & Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0003-2283-2353 Gregory R BowmanDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-2083-4892 Scott J HultgrenDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-8785-564X Funding
Infectious Diseases/Basic Microbial Pathogenic MechanismsT32AI007172 · NIAID · WASHINGTON UNIVERSITY · PI Daniel E. Goldberg, JENNIFER A PHILIPS · 1985 to 2026
$13.0MRational design and synthesis of small molecule inhibitors targeting unique pathogenic mechanisms in Gram- and Gram+ bacteria important in UTIU19AI157797 · NIAID · WASHINGTON UNIVERSITY · PI ELLEBEDY, ALI HASSAN · 2021 to 2025
$11.4MCHAPERONE-ASSISTED PILI ASSEMBLY IN PATHOGENIC E. COLIR01AI029549 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J., YUAN, PENG · 1991 to 2023
$5.7MPathogenic Fiber Formation in Bacteria: Structural BasisR37AI048689 · NIAID · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 2021 to 2026
$2.9MSpatially Organized Bacterial Interaction Networks in the Gut MicrobiotaR35GM150732 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Michael L Patnode · 2023 to 2026
$1.5MUnderstanding and controlling protein energy landscapes by combining simulations and experimentsR35GM152085 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Gregory Bowman · 2024 to 2026
$1.2MMetabolic And Spatial Competition For Dietary Fiber Between Commensal And Pathogenic Gut MicrobesK01DK124445 · NIDDK · WASHINGTON UNIVERSITY · PI PATNODE, MICHAEL L · 2020 to 2023
$639kNIAID NIH HHS R01 AI029549NIAID NIH HHS R37 AI048689NIAID NIH HHS T32 AI007172NIAID NIH HHS U19 AI157797NIDDK NIH HHS K01 DK124445NIGMS NIH HHS R35 GM150732NIGMS NIH HHS R35 GM152085
6 · The paper itselfAbstract
The Yeh chaperone-usher pathway (CUP) pilus adhesin is encoded in one-half of all
Indexed as
Adhesins, BacterialAdhesins, Escherichia coliBacterial AdhesionEscherichia coliEscherichia coli ProteinsFimbriae, BacterialPectinsMolecular Dynamics SimulationProtein BindingProtein Conformation, alpha-HelicalAdhesins, BacterialAdhesins, Escherichia coliEscherichia coli ProteinsPectins
Identifiers
PMID41499512
PMCPMC12778044
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