Evidence map›Paper›PMID 41499326›Full record

ArticlePhysiological reports2026

Lactate increases oxygen unloading of preconditioned blood from male elite breath-hold divers.

Thomas Kjeld, Egon Godthaab Hansen, Henrik Christian Arendrup, Jens Højberg, Anders Nedergaard, Thomas Krag, John Vissing

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thomas KjeldCopenhagen Neuromuscular Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-4348-9857
Egon Godthaab HansenDepartment of Anesthesiology, Herlev Hospital, Herlev, University of Copenhagen, Copenhagen, Denmark.
Henrik Christian ArendrupDepartment of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark.
Jens HøjbergDepartment of Cardiothoracic Anesthesiology, Rigshospitalet, Copenhagen, University of Copenhagen, Copenhagen, Denmark.
Anders NedergaardDepartment of Clinical Medicine, Faculty of Medicine, University of Copenhagen, Copenhagen, Denmark.
Thomas KragCopenhagen Neuromuscular Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
John VissingCopenhagen Neuromuscular Center, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical performance can be improved in aerobic athletes and breath-hold divers (BHD) by limb exposure to repetitive ischemia: remote ischemic conditioning (RIC). RIC protects against cardiac ischemia, and its blood-borne transferable substrate could be lactate. Accordingly, lactate added to whale blood increases oxygen unloading and adult seals possess higher cardiac lactate dehydrogenase activity (LDHa) than terrestrial mammals. Because BHD and adult diving mammals share adaptations to hypoxia, including lactate metabolization during apnea, we hypothesized that BHD compared to BMI/VO

Indexed as

Breath HoldingDivingIschemic PreconditioningLactic AcidOxygenOxygen ConsumptionAdultDiving and Hyperbaric MedicineHumansL-Lactate DehydrogenaseMaleLactic AcidL-Lactate DehydrogenaseOxygenerythorcyte metabolismfreedivingheart metabolismHypoxialactate

Identifiers

PMID41499326
PMCPMC12778441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.