Evidence map›Paper›PMID 41499232›Full record

ArticleCancer medicine2026

Molecular Deconvolution of Circulating "Other Cells": A Reliable Predictive Marker of Therapy Response and Survival in Neuroendocrine Tumor Patients Receiving

Mahesh K Padwal, Rahul V Parghane, Sandip Basu, Bhakti Basu

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Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Mahesh K PadwalMolecular Biology Division, Bhabha Atomic Research Centre, Mumbai, India.ORCID https://orcid.org/0000-0003-4715-1108
Rahul V ParghaneHomi Bhabha National Institute, Mumbai, India.
Sandip BasuHomi Bhabha National Institute, Mumbai, India.
Bhakti BasuMolecular Biology Division, Bhabha Atomic Research Centre, Mumbai, India.ORCID https://orcid.org/0000-0002-7381-6671

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the prognostic impact of pre-treatment circulating other cells on treatment response and survival in neuroendocrine tumor (NET) patients receiving Peptide Receptor Radionuclide Therapy (PRRT) with

methodsHealthy donors (HDs, n = 81) and NET patients (n = 137) were analyzed. Baseline circulating other cells proportions (OC%) were deconvoluted from RNA-Seq profiles using the Kassandra-B algorithm. Associations of OC% with demographic and clinicopathologic characteristics, tumor response to PRRT, and survival outcomes were evaluated.

resultsNET patients had a significantly higher OC% compared to HDs (median = 0.26 vs. 0.18, p = 0.0018). A positive correlation was observed between OC% and the tumor grade (G3 tumors: median = 0.47, G1 tumors: median = 0.22, p = 0.029) or disease burden (high: median = 0.32, low: median = 0.23, p = 0.016). The OC% was negatively associated with

conclusionsPre-treatment OC%, in conjunction with critical risk factors, is predictive of treatment response and survival in NET patients receiving

Indexed as

Neuroendocrine TumorsOctreotideOrganometallic CompoundsRadiopharmaceuticalsAdultAgedBiomarkers, TumorFemaleHumansMaleMiddle AgedPrognosisReceptors, PeptideTreatment OutcomeBiomarkers, Tumorlutetium Lu 177 dotatateOctreotideOrganometallic CompoundsRadiopharmaceuticalsReceptors, Peptide177Lu‐DOTATATE PRRTdisease control rateneuroendocrine tumorsother cell proportionsprognosis

Identifiers

PMID41499232
PMCPMC12778296

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