Evidence map›Paper›PMID 41499160›Full record

ReviewFEMS microbiology reviews2026

The honeybee gut microbiome: a novel multidimensional model of antimicrobial resistance transmission and immune homeostasis from environmental interactions to health regulation.

Qianmin Hai, Dufu Li, Tingyue Huang, Xiaoqun Dang, Jinshan Xu, Zhengang Ma, Zeyang Zhou

Abstract readReview
In one paragraph

Review in FEMS microbiology reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Insects · 2026
    Review
  4. Seasonal dynamics of the gut microbiota inFrontiers in insect science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qianmin HaiKey Laboratory of Pollinator Resources Conservation and Utilization of the Upper Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing Normal University, Chongqing 401331, China.
Dufu LiKey Laboratory of Pollinator Resources Conservation and Utilization of the Upper Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing Normal University, Chongqing 401331, China.
Tingyue HuangKey Laboratory of Pollinator Resources Conservation and Utilization of the Upper Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing Normal University, Chongqing 401331, China.
Xiaoqun DangKey Laboratory of Pollinator Resources Conservation and Utilization of the Upper Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing Normal University, Chongqing 401331, China.
Jinshan XuKey Laboratory of Pollinator Resources Conservation and Utilization of the Upper Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing Normal University, Chongqing 401331, China.ORCID 0000-0002-4963-3410
Zhengang MaKey Laboratory of Pollinator Resources Conservation and Utilization of the Upper Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing Normal University, Chongqing 401331, China.ORCID 0000-0001-6178-1988
Zeyang ZhouKey Laboratory of Pollinator Resources Conservation and Utilization of the Upper Yangtze River, Ministry of Agriculture and Rural Affairs, Chongqing Normal University, Chongqing 401331, China.

Funding

Chongqing Normal University YKC25026Earmarked Fund for China Agriculture Research System CARS-44-KXJ20National Natural Science Foundation of China 32372944Natural Science Foundation of Chongqing Municipality CSTB2024NSCQ-MSX0699Natural Science Foundation of Chongqing Municipality CSTB2025NSCQ-GPX1000
6 · The paper itself

Abstract

The honeybee gut microbiome has emerged as a model system in microbial ecology, valued for its structural stability and host specificity, and has garnered significant attention for elucidating universal principles of host-microbe interactions. This review advocates for the honeybee as a multidisciplinary model organism, highlighting the unique role of its gut microbiota in maintaining colony immune homeostasis, driving host co-evolution, unraveling the transmission mechanisms of antibiotic resistance genes (ARGs), and enhancing host adaptability to environmental stressors. By integrating multidimensional factors, including environmental gradients and apicultural practices, we construct an "Environment-Microbiota-Host Health" interaction framework to transcend the limitations of single-factor analyses. This framework provides a novel paradigm for the ecological containment of antimicrobial resistance, the conservation of pollinator resources, and microbiome-based engineering interventions. The review underscores the unique value of the honeybee model in unraveling social insect-microbe coevolution and resistance transmission dynamics, while also prospecting its application potential in developing novel antimicrobial peptides, designing probiotic formulations, and monitoring environmental resistance.

Indexed as

Drug Resistance, MicrobialGastrointestinal MicrobiomeHomeostasisAnimalsBeesHost Microbial Interactionsantimicrobial resistance transmissionbee modelhoneybee gut microbiomehorizontal gene transferhost–microbe interactionsOne Health

Identifiers

PMID41499160
PMCPMC12866650

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.