Evidence map›Paper›PMID 41499090›Full record

ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2026

Clinical Use of the Triglycerides/Glucose (TyG) Index in the Early Assessment of Metabolic Alterations and Cardiovascular Remodeling in Essential Hypertensive Patients.

Luigi Petramala, Gioacchino Galardo, Luca Marino, Francesco Circosta, Giulia Nardoianni, Francesco Baratta, Luca Caprioni Grasso, Federica Moscucci, Giuliano Tocci, Giovambattista Desideri and 1 more

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Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Luigi Petramala *Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy. luigi.petramala@uniroma1.it.ORCID http://orcid.org/0000-0003-4463-4956
Gioacchino Galardo *Department of Medical and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.
Luca MarinoDepartment of Mechanical and Aerospace Engineering, "Sapienza" University of Rome, Rome, Italy.
Francesco CircostaDepartment of Medical and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.
Giulia NardoianniDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy.
Francesco BarattaDepartment of Medical and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.
Luca Caprioni GrassoDepartment of Medical and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.
Federica MoscucciDepartment of Internal Medicine and Medical Specialities, Geriatric Unit, AOU Policlinico Umberto I, Rome, Italy.
Giuliano TocciDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Sant'Andrea Hospital, Rome, Italy.
Giovambattista DesideriDepartment of Medical and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.
Claudio LetiziaDepartment of Medical and Cardiovascular Sciences, "Sapienza" University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionObesity represents a significant public health problem, particularly due to its strong association with additional cardiovascular risk factors, such as hypertension, insulin resistance (IR), type 2 diabetes mellitus, metabolic syndrome (MS) and cardiovascular disease. IR is the underlying factor of the relationship between obesity and metabolic dysregulation. The identification of IR is crucial for early diagnosis, clinical management and specific treatment.

aimThis study aims to evaluate the diagnostic efficacy of the Triglycerides/Glucose (TyG) Index in identifying IR and target-organ damage in a cohort of patients with essential hypertension.

methodswe have evaluated 235 consecutive patients with essential hypertension (50.1% men and 49.9% women; mean age 51.9 ± 17.3 years), stratified for body mass index (BMI). Biochemical analysis and instrumental evaluation were assessed to identify target-organ damage.

resultsIncreased BMI was associated with higher values of blood pressure, glycaemia and triglycerides. In patients with higher BMI, we observed more prevalent target-organ damage, particularly cardiac remodeling (78.3%) and higher 24-h urinary albumin excretion (83.7±48 mg/L). The TyG index proved to be a stronger biomarker for identifying the development of MS (AUC 0.78) and cardiac remodeling (AUC 0.66).

conclusionsThis study confirms that obesity is correlated with a impaired hemodynamic and metabolic profile. The TyG index could represent an efficient and easy-to-use indicator for identifying both individuals developing MS and early cardiac remodeling, especially in normal-weight subjects.

Indexed as

Blood GlucoseBlood PressureEssential HypertensionInsulin ResistanceMetabolic SyndromeObesityTriglyceridesVentricular RemodelingAdultAgedBiomarkersBody Mass IndexCross-Sectional StudiesEarly DiagnosisFemaleHumansBiomarkersBlood GlucoseTriglyceridesCardiovascular riskHypertensionInsulin resistanceMyocardial remodelingObesitySubclinical organ damageTriglycerides/glucose (TyG) index

Identifiers

PMID41499090
PMCPMC12989022

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