ArticleProbiotics and antimicrobial proteins2026
Exploring the Probiotic and Antimicrobial Potential of Pediococcus Pentosaceus Isolates from Fish: Genomic and Functional Perspectives.
Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Complete Genome Sequence Analysis, Probiotic Properties, and Safety Assessment of Healthy Human-Derived Pediococcus pentosaceus.Probiotics and antimicrobial proteins · 2026Article
- Genomic and Phenotypic Characterization of Avian-DerivedAnimals : an open access journal from MDPI · 2026Article
- Gut-Derived Lactic Acid Bacteria,International journal of microbiology · 2026Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Aquaculture faces increasing challenges related to disease management and the need for sustainable alternatives to antibiotics that ensure productivity, fish welfare, and environmental sustainability. Probiotic bacteria, particularly lactic acid bacteria (LAB), have emerged as promising candidates for improving fish health through intestinal colonization, competitive exclusion of pathogens, and production of bioactive compounds. This study reports the phenotypic and genomic characterization of four Pediococcus pentosaceus strains (BE2, BE6, BE8, and BE9) isolated from the intestinal microbiota of freshwater fish (Cichlasoma spp.). Safety assessments revealed no hemolytic activity, coagulase production, or gelatinase activity, and antibiotic susceptibility profiles were consistent with international guidelines for probiotic candidates. The isolates demonstrated in vitro tolerance to acidic pH and bile salts, with viable counts decreasing by less than 2 log units under simulated gastrointestinal conditions. Adhesion assays using human Caco-2 cells showed approximately 30% adhesion efficiency. All strains exhibited growth on prebiotic substrates, including mannan oligosaccharides (MOS), fructo-oligosaccharides (FOS), and inulin (INU), with strain-specific preferences. Genomic analyses confirmed species-level identity and revealed biosynthetic gene clusters associated with the production of vitamins such as riboflavin, bacteriocins including penocin A and pediocin PA-1, alongside intrinsic resistance and stress response genes. Cell-free supernatants inhibited key aquaculture pathogens (Streptococcus agalactiae, Aeromonas hydrophila, and Francisella orientalis) in agar diffusion assays, suggesting antimicrobial potential mediated by bacteriocins identified in your genome. Therefore, the isolated strains exhibit promising functional and genomic characteristics, supporting their potential use as probiotics and components of synbiotic consortia for aquaculture applications.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.