Observational studyIndian pediatrics2026
Subclinical Cardiac Dysfunction in Childhood Cancer Survivors: Insights from Global Longitudinal Strain and Risk Factor Profiling.
Observational study in Indian pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association between body mass index and cardiopulmonary function in patients with chronic coronary syndrome.Annals of medicine · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate subclinical cardiac dysfunction and its association with treatment exposure and metabolic risk factors in a cohort of asymptomatic childhood cancer survivors (CCS).
methodsIn this cross-sectional, observational, single-centre study, pediatric and young adult CCS were evaluated. Eligible participants were diagnosed before 18 years of age and had completed cancer therapy at least two years prior to enrolment. Data on cancer history, treatment exposures, and comorbidities were extracted from electronic medical records. Cardiovascular evaluation included history, physical examination, electrocardiogram, and comprehensive 2D-echocardiography with global longitudinal strain (GLS) analysis. Cumulative anthracycline-equivalent doses (CAE) and radiation exposure to the heart were documented.
resultsOut of 456 CCS, anthracycline exposure was noted in 88% [mean (SD) CAE dose: 178.1 (123.2) mg/m
conclusionAbnormal GLS was prevalent in over 40% of asymptomatic CCS. Higher anthracycline exposure and presence of obesity and dyslipidemia were linked with subclinical cardiac dysfunction. These findings underscore the need for routine cardiac surveillance using strain imaging and aggressive management of modifiable risk factors to mitigate long-term cardiovascular morbidity in CCS.
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