Evidence map›Paper›PMID 41499017›Full record

ArticleClinical rheumatology2026

Interstitial lung disease in systemic sclerosis-a retrospective cross-sectional study in Taiwan.

Chih-Wei Liu, Yen-An Chang, Chia-Li Yu, Hung-Cheng Tsai, Wei-Sheng Chen, I-Cheng Ho, Yi-Syuan Sun, Hsien-Tzung Liao, Chang-Youh Tsai

Abstract read
In one paragraph

Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chih-Wei Liu *Division of Allergy, Immunology and Rheumatology, Taipei Municipal Gan-Dau Hospital (Managed By Taipei Veterans General Hospital), Taipei, Taiwan.ORCID http://orcid.org/0000-0003-0505-1766
Yen-An Chang *Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID http://orcid.org/0009-0007-7370-3769
Chia-Li YuDivision of Allergy, Immunology and Rheumatology, Department of Medicine, National Taiwan University Hospital, Taipei, Taiwan.ORCID http://orcid.org/0000-0003-4988-0400
Hung-Cheng TsaiDivision of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-0429-2608
Wei-Sheng ChenDivision of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
I-Cheng HoDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, U.S.A.ORCID http://orcid.org/0000-0003-3906-0345
Yi-Syuan SunDivision of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Hsien-Tzung LiaoDivision of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. htliao@vghtpe.gov.tw.ORCID http://orcid.org/0000-0001-5930-4840
Chang-Youh TsaiFaculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. cytsai1240@gmail.com.ORCID http://orcid.org/0000-0002-4154-4018

Funding

Regulatory roles of peptidylarginine deimination in elastogenisisR01HL158601 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HO, I-CHENG · 2022 to 2025
$2.2M
Fu Jen Catholic University Hospital IreneFu Jen Catholic University Hospital Paul American FoundationNational Institutes of Health (USA) R01 grant (HL158601)NHLBI NIH HHS R01 HL158601
6 · The paper itself

Abstract

INTRODUCTION/

objectivesInterstitial lung disease (ILD) is a crucial manifestation of systemic sclerosis (SSc), which has not been studied much in Asians.

methodsThe electronic medical records of 110 SSc patients between April 2000 and December 2020 were comprehensively examined, including clinical manifestations, laboratory tests, pulmonary functions, and high-resolution computerized tomography (HRCT) of the chest.

resultsAmong 26 men and 84 women with a median age of 61 years in SSc cohort, 52 (47.3%) presented with ILD. The actual prevalence of ILD in SSc cohort was estimated between 10.5% and 47.3%. The most common form was usual interstitial pneumonitis (UIP). The total lung capacity (TLC)/diffusion capacity of carbon monoxide (DLCO), renal function, and CRP were poorer in the SSc-ILD who smoked less than the counterpart without ILD. A weighted score incorporated from essential parameters (risk of ILD = TLC - 0.1 × ESR - 1.5 × CRP) has modest power (ROC AUC 0.7242) to predict ILD. The main causes of death in the SSc-ILD were infections (72.7%), pulmonary hypertension (PH, OR = 18.81, 95% CI = 2.11-167.70), and renal failure (OR = 33.6, 95% CI = 2.00-546.10).

conclusionThe SSc-ILD have lower TLC/DLCO, higher CRP, and poorer renal function than the SSc without ILD. Early-onset dyspnea, PH, and renal failure may be independent risk factors for mortality in SSc-ILD. Key Points • 110 SSc (M: F=26:84) were retrospectively analyzed for ILD, with 10.5-47.3% presenting with ILD (UIP the most). • Risk of ILD in SSc = TLC - 0.1 ×  ESR - 1.5 × CRP can apply in this cohort. • Death originated from infections, PH, and renal failure in addition to early-onset dyspnea in this cohort.

Indexed as

Lung Diseases, InterstitialScleroderma, SystemicAdultAgedCross-Sectional StudiesFemaleHumansHypertension, PulmonaryMaleMiddle AgedPrevalenceRespiratory Function TestsRetrospective StudiesRisk FactorsTaiwanTomography, X-Ray ComputedInterstitial lung diseases (ILD)MortalityPulmonary function testPulmonary hypertensionSystemic sclerosis (SSc)

Identifiers

PMID41499017
PMCPMC12858559

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.