Trial reportSleep & breathing = Schlaf & Atmung2026
Augmenting blood oxygen saturation via the sleep environment: a crossover trial of non-invasive indoor oxygen diffusion.
Trial report in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionContinuous Positive Airway Pressure (CPAP) is the standard treatment for Obstructive Sleep Apnea (OSA); however, patient adherence is often low. This study investigated the efficacy of a novel, non-invasive environmental strategy, elevating indoor oxygen (O2) levels, as a complementary approach for individuals at potential risk of OSA.
methodsA crossover trial with 20 participants was conducted, each undergoing two overnight polysomnography (PSG) tests: a sham control and an intervention night. During the intervention, the point-source oxygen diffusion system (80% purity, 8 L/min) increased the indoor O2 concentration. Indoor air quality (IAQ) parameters, including O2 and carbon dioxide (CO2) levels, along with standard PSG and blood oxygen saturation (SpO2) data, were simultaneously monitored.
resultsThe intervention significantly increased the indoor O2 by a median of 1.4% (p < 0.001). This change demonstrated a strong positive correlation (r = 0.76, p < 0.01) with the SpO2. Multivariate regression analysis further confirmed that a 1% increase in indoor O2 predicted a 0.5% increase in nocturnal SpO2 after controlling for age, sex, body mass index (BMI), and baseline OSA severity.
conclusionThese findings suggest that a moderate increase in indoor environmental oxygen can significantly improve nocturnal blood-oxygen saturation. This simple, non-invasive method may complement existing therapies, offering benefits to individuals with mild-to-moderate OSA, sleep disturbances at high altitudes, and nocturnal hypoxemia from chronic respiratory diseases such as COPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.