Evidence map›Paper›PMID 41498933›Full record

ReviewDermatologie (Heidelberg, Germany)2026

[Soft tissue fillers : Anatomical principles, mechanisms of action, and safe utilization in aesthetic medicine].

Michael Alfertshofer, Sebastian Cotofana

Abstract readEnglish AbstractReview
PubMed Publisher
In one paragraph

Review in Dermatologie (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael AlfertshoferDepartment of Oral and Maxillofacial Surgery, Charité University Hospital Berlin, Mittelallee 2, 13353, Berlin, Deutschland. michaelalfertshofer@gmx.de.
Sebastian CotofanaCentre for Cutaneous Research, Blizard Institute, Queen Mary University of London, London, Großbritannien.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soft tissue injections have become one of the most commonly performed minimally invasive procedures in aesthetic medicine. Concomitant to the rapid rise in performed treatments, reports of vascular complications have increased, including skin necrosis, and in rare cases even irreversible vision loss. The common denominator of these complications is the underlying anatomy: the face contains a dense and highly variable network of arteries and veins, interconnected through multiple anastomoses, making the prediction of their course difficult. An in-depth understanding of vascular and layer-specific anatomy as well as regional "danger zones" is hence essential for the safe and effective use of fillers and other injectable treatments. This article highlights the vascular and layered anatomy of the face, region-specific injection strategies, and evidence-based principles for the prevention and management of vascular complications.

Indexed as

Layer-specific anatomyMinimally invasive surgical proceduresRegional danger zonesVascular anatomyVascular complications

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.