Observational studyWorld journal of urology2026
Nocturia: when the heart wakes you up at night.
Observational study in World journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Nocturia and Left Ventricular End-Diastolic Pressure in Patients Undergoing Left Sided Cardiac Catheterization.Journal of community health · 2026Article
- Nocturia and heart failure: a vicious cycle involving sleep-induced hypogonadism and mitochondrial dysfunction.World journal of urology · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNocturia is a common and burdensome symptom that may reflect underlying cardiovascular dysfunction. While previous studies have linked nocturia to heart failure and fluid overload, direct hemodynamic evidence supporting this association remains limited.
objectiveTo evaluate the relationship between left- and right-sided filling pressures, particularly pulmonary artery wedge pressure (PAWP) and right atrial (RA) pressure, and nocturia severity in a cohort of patients undergoing right heart catheterization.
methodsWe conducted a prospective observational study of 74 adult patients undergoing right heart catheterization with documented PAWP. Nocturia frequency was assessed via structured interview and modeled as an ordinal outcome. Spearman's correlation and ordinal logistic regression were used to examine associations between PAWP and nocturia severity. Additional analyses explored relationships with right-sided filling pressures (right atrial, right ventricular end-diastolic (RVEDP), and pulmonary artery (PA) pressures). Because of multicollinearity, we fit separate adjusted ordinal logistic models including one pressure variable at a time (PAWP, RA, PA and RVEDP), each adjusted for left ventricular ejection fraction (LVEF), diuretic use, and peripheral edema (where available).
resultsPAWP was significantly associated with nocturia severity (ρ = 0.35, p = 0.003). In adjusted ordinal logistic regression, each 1 mmHg increase in PAWP was associated with a 7-10% higher odds of more frequent nighttime voiding. In separate multivariable models adjusted for LVEF, diuretic use, and peripheral edema both RA pressure (OR 1.15 per mmHg, p = 0.021) and RVEDP (OR 1.17 per mmHg, p = 0.002) were independently associated with greater nocturia severity, wereas PA pressure showed a trend (OR = 1.06 per mmHg, p = 0.078).
conclusionsBoth left- and right-sided ventricular filling pressures, particularly PAWP and RA pressure, are independently associated with nocturia severity in adjusted analyses. These findings support nocturia as a clinical marker of hemodynamic congestion, highlighting the importance of nocturia as a symptom of fluid overload and potential cardiac dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.