ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Clinical characteristics, etiology and outcome of new onset refractory status epilepticus in adults.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe analyzed clinical features and predictors of outcome in adult patients with new-onset refractory status epilepticus(NORSE).
methodsIn this retrospective cohort, we analyzed the data of 72 patients with NORSE followed-up for two or more years. Outcome was assessed by Glasgow Outcome Scale(GOS) at discharge and latest follow-up.
resultsMean age of the population was 35.13 ± 16.42 years and average follow-up was 60.34 ± 18.12 months. Average length of stay in hospital was 19.62 ± 14.68 days and mean ICU stay was14.43 ± 13.89 days. Of 72 patients with NORSE, 37(51.3%) patients progressed to super-refractory status epilepticus(SRSE). The most common etiology was cryptogenic(54%) followed by viral encephalitis(25%). Overall mortality was 27.8%. At discharge, 37 of 72 cases(51.4%) achieved a poor outcome (GOS 1-3). Among the survivors(n = 52), functional outcome improved over time and 84.6%(n = 44) achieved good outcome(GOS 4-5); however significant cognitive impairment was reported in 29(56%) and drug-resistant epilepsy in 31(60%). Although none of the factors predicted poor GOS outcome at discharge; etiology of viral encephalitis was associated with poor outcome at latest follow-up. Viral encephalitis, not able to achieve burst suppression on cEEG, medical complications and progression to SRSE predicted mortality during hospital stay.
conclusionDespite a prolonged clinical course and high mortality rate, more than 80% of adult survivors with NORSE attained a favourable functional outcome at long-term follow-up. None of the factors predicted the functional outcome at discharge; viral encephalitis was associated with poor outcome at latest follow-up. Significant cognitive impairment and drug-resistant epilepsy were reported in more than 50% of the survivors.
Indexed as
Identifiers
41498863What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.