ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
PROMs reveal early fall risk in the absence of clinical disability in people with multiple sclerosis.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFalls and fear of falling (FoF) are common in people with multiple sclerosis (pwMS), even in the absence of significant physical disability. To identify the determinants of falls in pwMS with low disability (EDSS < 4.0) and to examine the utility of patient-reported outcome measures (PROMs) in guiding timely fall prevention strategies.
methodsFifty RRMS patients (EDSS < 4.0, aged 18–50 years) and 30 age, sex, and education-matched healthy controls were assessed. Participants were evaluated for fall history (retrospective and prospective), static and dynamic balance, gait speed (T25FW), walking limitations (MSWS-12), cognitive function (MoCA), depression (BDI-II), and fear of falling (FES-I). Correlation and regression analyses were conducted to identify factors associated with FoF.
resultsFalls occurred in 48% of pwMS and 30% of healthy subjects (HC) (p = 0.1). FoF was significantly more common in pwMS (50%) than in HCs (23.3%, p = 0.001). MS patients who fell had significantly higher MSWS-12 and FES-I scores than non-fallers (p = 0.001 and p = 0.01, respectively). FoF positively correlated with age, disease duration, EDSS, static balance, and MSWS-12, and negatively with education level. In linear regression, MSWS-12 (p < 0.001) and disease duration (p = 0.03) were significant predictors of FoF.
conclusionFoF is common among pwMS even at low disability levels and may contribute to fall risk and activity restriction. PROMs, particularly MSWS-12 and FES-I, are valuable tools for identifying fall-prone individuals and should be integrated into routine clinical assessments to enable early intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.