Evidence map›Paper›PMID 41498815›Full record

ArticleAnalytical and bioanalytical chemistry2026

An inertial-acoustofluidic platform for bioanalysis: concurrent, high-precision, high-throughput separation of cells and bacteria.

Zhuoyang Wang, Xianglian Liu, Junping Duan, Binzhen Zhang, Yuanyuan Li, Langlang Yang, Haojian Wang

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Zhuoyang WangState Key Laboratory of Extreme Environment Optoelectronic Dynamic Measurement Technology and Instrument, North University of China, Taiyuan, Shanxi, China.
Xianglian LiuState Key Laboratory of Extreme Environment Optoelectronic Dynamic Measurement Technology and Instrument, North University of China, Taiyuan, Shanxi, China.
Junping DuanState Key Laboratory of Extreme Environment Optoelectronic Dynamic Measurement Technology and Instrument, North University of China, Taiyuan, Shanxi, China.
Binzhen ZhangState Key Laboratory of Extreme Environment Optoelectronic Dynamic Measurement Technology and Instrument, North University of China, Taiyuan, Shanxi, China. zhangbinzhen@nuc.edu.cn.
Yuanyuan LiDepartment of Nephrology, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.
Langlang YangState Key Laboratory of Extreme Environment Optoelectronic Dynamic Measurement Technology and Instrument, North University of China, Taiyuan, Shanxi, China.
Haojian WangState Key Laboratory of Extreme Environment Optoelectronic Dynamic Measurement Technology and Instrument, North University of China, Taiyuan, Shanxi, China.

Funding

China Scholarship Council of Shanxi Province Grant No. 2022-143National Natural Science Foundation of China No. 52175555Research Fund of the Key Laboratory of North University of China No. 2023-SYSJJ-03
6 · The paper itself

Abstract

Efficient separation of cancer cells from whole blood is vital for early cancer diagnosis. However, disease progression often causes complications that reduce survival, such as cholangitis in liver cancer due to bile-duct compression, with Escherichia coli (E. coli) and Klebsiella as common pathogens. To address this, we developed a sheathless microfluidic sorter that integrates inertial focusing with surface acoustic wave (SAW) manipulation to simultaneously isolate cancer cells and bacteria. Specifically, we introduce a label-free, SAW-driven microfluidic platform that couples passive inertial focusing with active SAW manipulation to enable concurrent separation of cancer cells and bacteria; Cr/Au interdigital transducers (IDTs) are patterned on a 128° Y-cut LiNbO₃ substrate. The system first employs a contraction-expansion microchannel to achieve preliminary separation. Larger particles are then deflected by a slanted interdigital transducer (S-IDT), improving bacterial sorting purity. Small particles are enriched at the first outlet (purity > 96%), and the remaining targets are further refined by a focusing interdigital transducer (F-IDT). Tests with polystyrene (PS) particles achieved >96% purity, and in clinical samples, sorting efficiency and purity exceeded 93% for HepG2 cells and E. coli, with HepG2 viability above 94%. This compact platform unifies active and passive mechanisms, offering promise for early diagnosis and real-time monitoring of complications.

Indexed as

AcousticsCell SeparationEscherichia coliMicrofluidic Analytical TechniquesEquipment DesignHep G2 CellsHumansAcoustofluidicCell and bacteria separationInertial focusingLiver cancer liquid biopsyMicrofluidic sortingSurface acoustic waves

Identifiers

PMID41498815

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.