Evidence map›Paper›PMID 41498662›Full record

ReviewIndian journal of pharmacology2026

A quiet but growing threat: Global perspectives on antifungal resistance and future therapeutic approaches.

Swathi Gurajala, Meera Challapilla

Abstract readReview
In one paragraph

Review in Indian journal of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Swathi GurajalaDepartment of Respiratory Care, College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Meera ChallapillaEast Suffolk and North Essex NHS Foundation Trust, Ipswich Hospital, Ipswich, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractAntifungal drug resistance is an escalating global health concern that threatens the effective treatment of fungal infections in both clinical and environmental settings. This review synthesizes developments, focusing on molecular and physiological mechanisms of resistance, key contributing factors, and associated therapeutic limitations. Through selected international case studies over the past 5 years (2020-2025), we illustrate the clinical and ecological consequences of resistant fungal pathogens and emphasize the need for coordinated global responses. We also discuss integrated strategies to mitigate this threat, including strengthened surveillance systems, optimized antifungal stewardship, and advancements in diagnostic tools and therapeutic innovation. By consolidating recent insights and identifying critical research gaps, this review aims to inform future investigations and guide policy frameworks to combat antifungal resistance worldwide.

Indexed as

Antifungal AgentsDrug Resistance, FungalMycosesAnimalsFungiGlobal HealthHumansAntifungal AgentsAntifungal agentsantifungal drug resistanceantifungal stewardshipcase studiesclinical and environmental settingsfungal infectionsglobal healthpublic healthresistance mechanismstherapeutic challenges

Identifiers

PMID41498662
PMCPMC12875527

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.