Evidence map›Paper›PMID 41498647›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Stimuli-Responsive Supramolecular Biomaterials for Cancer Theranostics.

Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao

Abstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Stimuli-Responsive Supramolecular Biomaterials for Cancer Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenting HuDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Binglin YeDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.
Guocan YuKey Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, China.
Feihe HuangStoddart Institute of Molecular Science, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
Zhengwei MaoDepartment of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, China.ORCID https://orcid.org/0000-0001-7990-2856

Funding

National Natural Science Foundation of China 22161132027
6 · The paper itself

Abstract

The ultimate goal of cancer theranostics is to deliver imaging agents and therapeutic cargo to tumor sites when and where they are required. "Smart" systems─including targeted and tailored releases with excellent spatial, temporal, and dosage control─should be developed. Supramolecular interactions with dynamic, reversible, and directional features enable the design of biomaterials with ordered architectures, tailored morphologies, multiple types of cargo, and controllable functions. Such supramolecular biomaterials are good candidates for oncology applications, as they optimize therapeutic efficacy while minimizing systemic adverse effects. This review summarizes recent advances in intelligent supramolecular biomaterials, with a specific focus on their spatiotemporal control in cancer theranostics. These biomaterials exploit endogenous and exogenous stimuli to trigger their morphological transformation. In particular, their construction approach and working mechanism, which are crucial in guiding tumor theranostics, are elaborated. Furthermore, the significant challenges in clinical translation and future perspectives for such biomaterials are discussed.

Indexed as

Precision MedicineBiocompatible MaterialsDrug Delivery SystemsGlutathione DisulfideHumansMicellesMolecular Targeted TherapyNeoplasmsTheranostic NanomedicineTumor MicroenvironmentBiocompatible MaterialsGlutathione DisulfideMicellescancer theranosticssmart materialsstimuli‐responsivesupramolecular chemistrytumor microenvironment

Identifiers

PMID41498647
PMCPMC12915107

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.